Analysis of Cerebrospinal Fluid from Chronic Fatigue Syndrome Patients for Multiple Human Ubiquitous Viruses and Xenotropic Murine Leukemia-Related Virus
Analysis of Cerebrospinal Fluid from Chronic Fatigue Syndrome Patients for Multiple Human Ubiquitous Viruses and Xenotropic Murine Leukemia-Related Virus
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DOI：
10.1002/ana.22389
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发表时间：
2011-04-01
影响因子：
11.2
通讯作者：
Eshoo, Mark W.
中科院分区：
文献类型：
--
作者：
Schutzer, Steven E.;Rounds, Megan A.;Eshoo, Mark W.
最近的报告显示，许多慢性疲劳综合征(CFS)患者的血液中含有逆转录病毒--异嗜性小鼠白血病相关病毒(XMRV)；其他研究无法复制这一发现。一个有用的下一步是检查脑脊液，因为在一些患者中，CFS被认为是一种大脑疾病。由于血脑屏障的完整性，在中枢神经系统中发现微生物比在血液中发现微生物具有更大的意义。我们用聚合酶链式反应技术检测了43例CFS患者的脑脊液，但没有发现XMRV或多种其他常见病毒，这表明有必要探索其他原因或致病机制。Ann Neurol 2011；69：735-738
Recent reports showed many patients with chronic fatigue syndrome (CFS) harbor a retrovirus, xenotropic murine leukemia-related virus (XMRV), in blood; other studies could not replicate this finding. A useful next step would be to examine cerebrospinal fluid, because in some patients CFS is thought to be a brain disorder. Finding a microbe in the central nervous system would have greater significance than in blood because of the integrity of the blood-brain barrier. We examined cerebrospinal fluid from 43 CFS patients using polymerase chain reaction techniques, but did not find XMRV or multiple other common viruses, suggesting that exploration of other causes or pathogenetic mechanisms is warranted. ANN NEUROL 2011; 69: 735-738