Liquid meal composition, postprandial satiety hormones, and perceived appetite and satiety in obese women during acute caloric restriction.
Liquid meal composition, postprandial satiety hormones, and perceived appetite and satiety in obese women during acute caloric restriction.
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DOI：
10.1530/eje-12-0884
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发表时间：
2013-04
影响因子：
5.8
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中科院分区：
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本研究的目的是比较急性（24小时）热量限制期间肥胖女性的餐后饱腹感调节激素反应（胰多肽（PP）和肽酪氨酸酪氨酸（PYY））和视觉模拟量表（VAS）评估的高蛋白（HP）和高碳水化合物（HC）膳食之间的食欲和饱腹感。11名肥胖的绝经前妇女完成了两个条件，在随机顺序中，他们消耗了1500卡路里的六个250卡路里的HP餐或六个250卡路里的HC餐超过12小时的时间。在基线时和此后每20分钟采集血样，并分析PP和PYY浓度。在这些相同的时间点，用VAS评估感知的饥饿感和饱腹感。使用增量曲线下面积（iAUC）比较餐后反应。HP条件下（PP：4727±1306 pg/ml×12 h，PYY：1373±357 pg/ml × 12 h）的12 h PP和PYY iAUC大于HC条件下（PP：2300±528 pg/ml × 12 h，PYY：754±246 pg/ml×12 h）（P≤0.05）。饥饿感和饱腹感在不同条件下无差异（P>0.05）。在这两种情况下，PYY和感觉到的饱腹感的最大变化发生在早餐后。这些数据表明，在减肥前急性热量限制期间的肥胖女性中，i）与HC膳食相比，液体HP膳食导致更高的餐后PP和PYY浓度，这种效应与不同的食欲或饱腹感反应无关，以及ii）膳食诱导的PYY和饱腹感变化在早晨期间最大，无论膳食常量营养素组成如何。
The purpose of this study was to compare postprandial satiety regulating hormone responses (pancreatic polypeptide (PP) and peptide tyrosine tyrosine (PYY)) and visual analog scale- (VAS) assessed perceived appetite and satiety between liquid high-protein (HP) and high-carbohydrate (HC) meals in obese women during acute (24-h) caloric restriction. Eleven obese premenopausal women completed two conditions in random order in which they consumed 1500 calories as six 250-calorie HP meals or six 250-calorie HC meals over a 12-h period. Blood samples were taken at baseline and every 20 min thereafter and analyzed for PP and PYY concentrations. At these same points, perceived hunger and fullness were assessed with a VAS. The incremental area under the curve (iAUC) was used to compare postprandial responses. The 12-h PP and PYY iAUC were greater (P≤0.05) during the HP condition (PP: 4727±1306 pg/ml×12 h, PYY: 1373±357 pg/ml×12 h) compared with the HC condition (PP: 2300±528 pg/ml×12 h, PYY: 754±246 pg/ml×12 h). Perceived hunger and fullness were not different between conditions (P>0.05). The greatest changes in PYY and perceived fullness occurred after the morning meals during both conditions. These data suggest that in obese women during acute caloric restriction before weight loss, i) liquid HP meals, compared with HC meals, result in greater postprandial PP and PYY concentrations, an effect not associated with differential appetite or satiety responses, and ii) meal-induced changes in PYY and satiety are greatest during the morning period, regardless of dietary macronutrient composition.