Mucinous adenocarcinoma of the submandibular gland
Mucinous adenocarcinoma of the submandibular gland
复制标题
颌下腺粘液性腺癌
DOI：
10.1002/1097-0142(19901015)66:8
复制
发表时间：
1990
期刊：
影响因子：
6.2
通讯作者：
Y. Tatemoto
中科院分区：
文献类型：
--
作者：
T. Osaki;Jyusui Hirota;A. Ohno;Y. Tatemoto
一种罕见的肿瘤，不容易分类之间发表的组织学类别的唾液腺肿瘤的报告。肿瘤发生在一名78岁女性的颌下腺内，侵犯下颌骨并转移至区域淋巴结。组织学上，立方细胞具有透明的细胞质和移位的圆形核增殖，并表现出腺瘤样模式。可见许多被肿瘤细胞束包围的囊性空间，囊性空间内充满粘液物质，肿瘤细胞似乎分泌粘液，但未观察到表皮样细胞或乳头状外观。电镜下，胞浆内可见大量低电子密度的粘液滴，瘤细胞腔面可见稀疏的不规则微绒毛。粘蛋白组织化学，包括反常刀豆球蛋白A染色，显示肿瘤细胞含有中性和酸性粘蛋白，这些被确定为II类和III类粘液物质。在第一次检查后6年，除了复发性转移性颈淋巴结外，没有发现其他肿瘤性病变，似乎该肿瘤是一种罕见的原发性下颌下腺粘液腺癌。
A rare tumor not easily classifiable among published histologic categories for salivary gland tumors is reported. The neoplasm developed within the submandibular gland of a 78‐year‐old woman with invasion of the mandible and metastasis to regional lymph nodes. Histopathologically, cuboidal cells possessing clear cytoplasm and displaced round nuclei proliferated and exhibited an adenomatous pattern. Many cystic spaces surrounded by tumor cell strands were seen, mucus substance filled in the cystic spaces, and the tumor cells seemed mucus‐secreting, but neither epidermoid cells nor papillary appearance could be observed. Electromicroscopically, numerous mucous droplets of low electron density were prominent in the cytoplasm, and the tumor cells had sparce irregular microvilli on the luminal surface. Mucin histochemistry, including paradoxical concanavalin A staining, revealed that the tumor cells contained neutral and acid mucins, and these were identified as class II and III mucosubstances. No other neoplastic lesion, except recurrent metastatic neck nodes, has been detected 6 years after the first examination, and it seems that the tumor is a rare primary mucinous adenocarcinoma of the submandibular gland.