Single cell mechanics: Stress stiffening and kinematic hardening
Single cell mechanics: Stress stiffening and kinematic hardening
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DOI：
10.1103/physrevlett.100.238102
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发表时间：
2008-06-13
影响因子：
8.6
通讯作者：
Ott, Albrecht
中科院分区：
文献类型：
--
作者：
Fernandez, Pablo;Ott, Albrecht
细胞的力学性质是生物体的基础，但仍然知之甚少。我们报告了一个全面的现象学框架的复杂流变学的单个成纤维细胞：叠加的弹性硬化和粘塑性运动硬化。尽管活细胞很复杂，但它的机械特性可以被转换成简单的、定义明确的规则。我们的研究结果揭示了交联滑移在确定机械单元强度和鲁棒性中的关键作用。
Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the complex rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic kinematic hardening. Despite the complexity of the living cell, its mechanical properties can be cast into simple, well-defined rules. Our results reveal the key role of crosslink slippage in determining mechanical cell strength and robustness.