Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging
Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging
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DOI：
10.1007/s13204-019-01098-y
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发表时间：
2020-08-01
影响因子：
--
通讯作者：
Sasaki, Ryohei
中科院分区：
文献类型：
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作者：
Akasaka, Hiroaki;Mukumoto, Naritoshi;Sasaki, Ryohei
纳米颗粒（NP）可用于放射疗法。目前，全球正在努力开发具有对比效果和抗肿瘤效果的新型二氧化钛纳米颗粒（TiO 2-NPs）。在本研究中，使用临床磁共振成像（MRI）系统和临床计算机断层扫描（CT）扫描仪评价了TiO 2-NP的图像对比度特性，因为在几份报告中已经报道了TiO 2-NP作为抗癌剂的用途。在T2加权像上观察到对照和TiO 2-NP样品之间的可视化有明显差异。这些结果表明，TiO（2）可通过表面化学基团的修饰，作为具有放射增敏能力和放射诊断能力的新型治疗诊断药物，并可作为药物释放系统的组成部分。
Nanoparticles (NPs) are useful for radiotherapy. Currently, efforts are underway globally for the development of novel titanium dioxide NPs (TiO2-NPs) that exhibit both contrast effects and anti-tumor effects. In this study, the image contrast properties of TiO2-NPs were evaluated using a clinical magnetic resonance imaging (MRI) system and a clinical computed tomography (CT) scanner, as the use of TiO2-NPs as an anti-cancer agent has been reported in several reports. An obvious difference in visualization was observed between the control and TiO2-NP samples onT(2)-weighted images. These results suggest that TiO(2)can potentially be used as a novel theranostic drug with radiosensitizing ability and radiological diagnostic ability, through modification of chemical groups on its surface, and as a component of drug delivery systems.