DNA looping and physical constraints on transcription regulation
DNA looping and physical constraints on transcription regulation
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DOI：
10.1016/s0022-2836(03)00764-2
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发表时间：
2003-08-29
影响因子：
5.6
通讯作者：
Leibler, S
中科院分区：
文献类型：
--
作者：
Vilar, JMG;Leibler, S
DNA环参与转录调控，例如，通过允许远端结合位点协同作用。在这里，我们研究这个过程，并比较基于有环和无环抑制的不同调节机制。在一个简单的数学模型的乳糖操纵子，我们表明，基于DNA循环的调节，除了增加镇压水平，可以减少转录的波动，并在同一时间，降低了对调节蛋白的数量变化的敏感性。因此，成环能够规避仅基于与单个操纵基因位点结合的机制所固有的一些约束，并提供了调节转录的平均性质及其波动的机制。(C)2003爱思唯尔有限公司。保留所有权利。
DNA looping participates in transcriptional regulation, for instance, by allowing distal binding sites to act synergistically. Here, we study this process and compare different regulatory mechanisms based on repression with and without looping. Within a simple mathematical model for the lac operon, we show that regulation based on DNA looping, in addition to increasing the repression level, can reduce the fluctuations of transcription and, at the same time, decrease the sensitivity to changes in the number of regulatory proteins. Looping is thus able to circumvent some of the constraints inherent to mechanisms based solely on binding to a single operator site and provides a mechanism to regulate the average properties of transcription and its fluctuations. (C) 2003 Elsevier Ltd. All rights reserved.