A diastereoselective synthesis of 2,4-disubstituted piperidines: Scaffolds for drug discovery
A diastereoselective synthesis of 2,4-disubstituted piperidines: Scaffolds for drug discovery
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DOI：
10.1021/ol006589o
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发表时间：
2000-11-16
期刊：
影响因子：
5.2
通讯作者：
Scott, B
中科院分区：
文献类型：
--
作者：
Watson, PS;Jiang, B;Scott, B
[图示]开发了一种非对映选择性合成 2,4-二取代哌啶的方法，只需改变反应顺序即可完全控制反应选择性。这些靶标为药物发现提供了方便的平台，其中包含易于修改的多样性点。
[GRAPHICS]A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms for drug discovery which contain easily modified points of diversity.