Catalytic mechanism and regulation of mammalian adenylyl cyclases.
Catalytic mechanism and regulation of mammalian adenylyl cyclases.
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DOI：
10.1124/mol.54.2.231
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发表时间：
1998-08
影响因子：
3.6
通讯作者：
Wei-Jen Tang;James H. Hurley
中科院分区：
文献类型：
--
作者：
Wei-Jen Tang;James H. Hurley
cAMP是激素、神经递质、气味剂和趋化因子的细胞内信号传导途径中的关键参与者。通过激活PKA和环核苷酸门控离子通道，这种多变的第二信使可以改变细胞属性，如膜电位和细胞增殖速率。
cAMP is a key player in the intracellular signaling pathways of hormones, neurotransmitters, odorants, and chemokines. By activating PKA and cyclic nucleotide-gated ion channels, this protean second messenger can change cellular attributes as diverse as the membrane potential and the rate of cell