Individual and neighborhood socioeconomic status and inflammation in Mexican American women: what is the role of obesity?
Individual and neighborhood socioeconomic status and inflammation in Mexican American women: what is the role of obesity?
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DOI：
10.1097/psy.0b013e31824f5f6d
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发表时间：
2012-06
影响因子：
3.3
通讯作者：
Matthews KA
中科院分区：
文献类型：
--
作者：
Gallo LC;Fortmann AL;de Los Monteros KE;Mills PJ;Barrett-Connor E;Roesch SC;Matthews KA
Inflammation may represent a biological mechanism underlying associations of socioeconomic status (SES) with cardiovascular disease (CVD). The current study examined relationships of individual and neighborhood SES with inflammatory markers in Mexican-American women and evaluated contributions of obesity and related heath behaviors to these associations. A random sample of 284 Mexican-American women (mean age 49.74 years) was recruited from socioeconomically diverse South San Diego communities. Women completed measures of sociodemographic characteristics and health behaviors, and a physical examination with fasting blood draw for assay of plasma C-reactive-protein (CRP), interleukin-6 (IL-6), and soluble intercellular adhesion molecule-1 (sICAM-1). Neighborhood SES was extracted from the US Census Bureau 2000 database. In multilevel models, a one-standard deviation (SD) higher individual and neighborhood SES related to a 27.35% and 23.56% lower CRP (ps < .01), a 7.04% and 5.32% lower sICAM-1 (ps < .05), and a 10.46% (p < .05) and 2.40% lower IL-6 level (NS), respectively. Controlling for individual SES, a one-SD higher neighborhood SES related to a 18.05% lower CRP (p = .07); there was no unique effect of neighborhood SES for IL-6 or sICAM-1. Differences in body mass index, waist circumference, and dietary fat consumption contributed significantly to SES-inflammation associations. The findings support a link between SES and inflammatory markers in Mexican-American women, and implicate obesity and dietary fat in these associations. Additional effects of neighborhood SES were not statistically significant. These findings should be viewed tentatively because the relatively small sample size limits the evaluation of multiple contextual factors.
