A receptor based model for pattern formation in Hydra
A receptor based model for pattern formation in Hydra
复制标题
基于受体的水螅模式形成模型
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
W. Muller
中科院分区：
文献类型：
--
作者：
J. Sherratt;P. Maini;W. Jäger;W. Muller
我们提出了一个新的理论模型的模式调节水螅。我们的模型将位置值和“头部激活电位”视为相同细胞特性的表现，即通过表面受体与细胞结合的调节生化物质的量。该模型的中心最近发现的头和脚形成机制之间的相互作用，我们提出，头部和脚的形成可以通过受体生化结合控制。位置值由结合受体的密度决定，极性由每个细胞受体数量的梯度确定。细胞之间对这种生化调节剂的局部竞争意味着，将组织从体柱的较高区域移植到较低区域会导致移植组织的位置价值增加，而牺牲其新邻居。我们表明，这种局部竞争效应的发生，如果除了受体密度的梯度，也有一个梯度的酶，积极降解的生化调节剂的分泌速率。我们表明，这两个平行梯度的组合，该模型能够捕捉到广泛的结果，从切割和嫁接实验。特别是，该模型预测，多余的头会导致多余的脚的形成，而多余的脚不会导致新的头的形成。
We propose a new theoretical model for pattern regulation in Hydra. Our model treats positional value and "head activation potential" as manifestations of the same cellular property, the amount of a regulatory biochemical bound to the cells via surface receptors. The model centres on the recently discovered interaction between the head- and foot-forming mechanisms, and we propose that both head and foot formation could be controlled by receptor-biochemical binding. Positional value is determined by the density of bound receptors, and polarity is established by a gradient in the number of receptors per cell. The local competition between cells for this biochemical regulator means that transplantation of tissue from a higher to a lower region of the body column causes an increase in the positional value of the transplanted tissue, at the expense of its new neighbours. We show that a local competition effect of this kind occurs if, in addition to the gradient in receptor density, there is also a gradient in the secretion rate of an enzyme that actively degrades the biochemical regulator. We show that with the combination of these two parallel gradients, the model is able to capture a wide range of results from cutting and grafting experiments. In particular, the model predicts that supernumerary heads induce the formation of supernumerary feet, whereas supernumerary feet do not induce new heads to form.