Relationship between perceived cognitive dysfunction and objective neuropsychological performance in persons with rheumatoid arthritis.
Relationship between perceived cognitive dysfunction and objective neuropsychological performance in persons with rheumatoid arthritis.
复制标题
类风湿关节炎患者感知认知功能障碍与客观神经心理学表现之间的关系。
DOI：
10.1002/acr.21814
复制
发表时间：
2013
影响因子：
4.7
通讯作者：
Julian,Laura
中科院分区：
文献类型：
--
作者：
Shin,SoYoung;Katz,Patricia;Julian,Laura
客观研究表明，慢性病患者的感知认知功能障碍与客观神经心理学表现之间存在差距。我们探讨了类风湿性关节炎 (RA) 患者的这种关系。方法来自 RA 纵向队列研究的个体参加了一项研究访问，其中包括身体、心理社会、认知和生物指标。使用感知缺陷问卷（PDQ；范围 0-20，分数越高=感知损伤越大）评估主观认知功能障碍。客观认知障碍通过 12 项标准化神经心理学指标进行评估，得出 16 个指数。在每次测试中，如果受试者的表现低于基于年龄的人群标准 1 SD，则被归类为受损。认知功能总分通过将转换后的分数相加计算得出（范围 0-16，分数越高=损伤越大）。多元线性回归分析确定了总认知功能评分与 PDQ 评分的关系，并控制了性别、种族、婚姻状况、收入、教育、疾病持续时间、疾病严重程度、抑郁和疲劳。 结果纳入了 120 名受试者（平均±SD 年龄 58.5±11.0 岁）。总认知功能和 PDQ 的平均值±SD 分数分别为 2.5 ± 2.2（范围 0-10）和 5.8 ± 3.8（范围 0-16）。多变量分析显示，认知功能总分与PDQ评分之间不存在显着相关性。然而，抑郁和疲劳（分别为 β = 0.32，P < 0.001 和 β = 0.31，P = 0.001）与 PDQ 评分显着相关。 结论 研究结果强调了认知障碍的主观和客观测量之间的差距，以及在临床环境中在认知症状背景下考虑心理因素的重要性。
ObjectiveResearch shows a gap between perceived cognitive dysfunction and objective neuropsychological performance in persons with chronic diseases. We explored this relationship in persons with rheumatoid arthritis (RA).MethodsIndividuals from a longitudinal cohort study of RA participated in a study visit that included physical, psychosocial, cognitive, and biologic metrics. Subjective cognitive dysfunction was assessed using the Perceived Deficits Questionnaire (PDQ; range 0–20, where higher scores = greater perceived impairment). Objective cognitive impairment was assessed using a battery of 12 standardized neuropsychological measures yielding 16 indices. On each test, subjects were classified as impaired if they performed 1 SD below the age‐based population norms. Total cognitive function scores were calculated by summing the transformed scores (range 0–16, where higher scores = greater impairment). Multiple linear regression analyses determined the relationship of the total cognitive function score with the PDQ score, controlling for sex, race, marital status, income, education, disease duration, disease severity, depression, and fatigue.ResultsOne hundred twenty subjects (mean ± SD age 58.5 ± 11.0 years) were included. Mean ± SD scores of total cognitive function and the PDQ were 2.5 ± 2.2 (range 0–10) and 5.8 ± 3.8 (range 0–16), respectively. In multivariate analysis, there was no significant relationship between the total cognitive function score and the PDQ score. However, depression and fatigue (β = 0.32,P< 0.001 and β = 0.31,P= 0.001, respectively) were significantly associated with the PDQ score.ConclusionThe findings emphasize the gap between subjective and objective measures of cognitive impairment and the importance of considering psychological factors within the context of cognitive symptoms in clinical settings.