Cortico-thalamic hypo- and hyperconnectivity extend consistently to basal ganglia in schizophrenian
Cortico-thalamic hypo- and hyperconnectivity extend consistently to basal ganglia in schizophrenian
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DOI：
10.1038/s41386-018-0059-z
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发表时间：
2018-10-01
影响因子：
7.6
通讯作者：
Sorg, Christian
中科院分区：
文献类型：
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作者：
Avram, Mihai;Brandl, Felix;Sorg, Christian
精神分裂症的特征是前额叶-边缘皮质和丘脑核团之间的连通性低下或内在功能连通性(IFC)降低，以及初级感觉运动皮质和丘脑核团之间的连通性高或IFC增加。然而，皮质-丘脑IFC与更大的、结构上定义的皮质-纹状-苍白-丘脑-皮质(CSPTC)环路重叠。如果这种重叠与固有的低/高连接性有关，这表明：(1)皮质-皮质下低/高连接性的模式一致地从丘脑延伸到基底节核团；(2)这种持续的低/高连接性可能与不同的症状维度明显相关，即认知障碍和精神障碍。为了验证这一假设，57名精神分裂症患者和61名健康对照组接受了静息状态功能磁共振成像(FMRI)和临床行为测试的评估。通过fMRI时间进程之间的部分相关性来评估从固有皮质网络进入丘脑、纹状体和苍白球的IFC。在患者中，覆盖前额-边缘皮质的突起网络与丘脑内侧背侧、纹状体和苍白球腹侧部分连接不足；这些IFC连接不足模式相互关联，并与患者的认知损害有关。相比之下，覆盖初级感觉运动皮质的听觉-感觉-运动网络与丘脑前腹核、纹状体和苍白球背侧部分高度连接；这些IFC-高连接模式同样彼此相关，并与患者的精神症状有关。结果表明，前额叶-边缘连接不足和初级感觉运动高连接一致地延伸到皮质下核团，特别是跨越不同的症状维度。数据支持精神分裂症患者CSPTC回路内一致的皮质-皮质下低/高连接性模型。
Schizophrenia is characterized by hypoconnectivity or decreased intrinsic functional connectivity (iFC) between prefrontal-limbic cortices and thalamic nuclei, as well as hyperconnectivity or increased iFC between primary-sensorimotor cortices and thalamic nuclei. However, cortico-thalamic iFC overlaps with larger, structurally defined cortico-striato-pallido-thalamo-cortical (CSPTC) circuits. If such an overlap is relevant for intrinsic hypo-/hyperconnectivity, it suggests (i) that patterns of cortico-subcortical hypo-/ hyperconnectivity extend consistently from thalamus to basal ganglia nuclei; and (ii) such consistent hypo-/hyperconnectivity might link distinctively but consonant with different symptom dimensions, namely cognitive and psychotic impairments. To test this hypothesis, 57 patients with schizophrenia and 61 healthy controls were assessed by resting-state functional magnetic resonance imaging (fMRI) and clinical-behavioral testing. IFC from intrinsic cortical networks into thalamus, striatum, and pallidum was estimated by partial correlations between fMRI time courses. In patients, the salience network covering prefrontal-limbic cortices was hypoconnected with the mediodorsal thalamus and ventral parts of striatum and pallidum; these iFC-hypoconnectivity patterns were correlated both among each other and specifically with patients' impaired cognition. In contrast, the auditorysensorimotor network covering primary-sensorimotor cortices was hyperconnected with the anterior ventral nucleus of the thalamus and dorsal parts of striatum and pallidum; these iFC-hyperconnectivity patterns were likewise correlated among each other and specifically with patients' psychotic symptoms. The results demonstrate that prefrontal-limbic hypoconnectivity and primary-sensorimotor hyperconnectivity extend consistently across subcortical nuclei and specifically across distinct symptom dimensions. Data support the model of consistent cortico-subcortical hypo-/hyperconnectivity within CSPTC circuits in schizophrenia.