Parallel processing across neural systems: Implications for a multiple memory system hypothesis
Parallel processing across neural systems: Implications for a multiple memory system hypothesis
复制标题
DOI：
10.1016/j.nlm.2004.07.007
复制
发表时间：
2004-11-01
影响因子：
2.7
通讯作者：
Davis, DM
中科院分区：
文献类型：
--
作者：
Mizumori, SJY;Yeshenko, O;Davis, DM
大脑记忆系统组织的一个常见概念是，不同类型的记忆是由不同的神经系统介导的。对这一观点的有力支持来自于一些研究，这些研究表明，在海马体、纹状体和杏仁核的选择性断裂之后，空间记忆、反应记忆和情绪记忆之间存在双重（或三重）分离。在这里，我们研究了海马体和纹状体神经活动模式在多大程度上支持多重记忆系统的观点。比较了空间迷宫和反应迷宫任务中海马和纹状体神经与行为的关系。无论任务要求如何，在两个结构中都发现了位置（或地点）、运动和奖励特定的放电模式。许多，但不是全部，海马和纹状体神经元的位置域同样受到视觉和奖励环境变化的影响，而不管认知需求如何。此外，许多（但不是全部）海马和纹状体运动敏感神经元在视觉环境改变后表现出显著的行为相关变化，与认知策略无关。同样，不管任务是什么，在对两个结构记录的细胞进行奖励条件操作后，也观察到类似的部分重组。假设在上下文变化中持续存在的表征反映了学习到的信息，我们得出以下结论。首先，部分重组的一致模式支持了一种观点，即空间、反应和强化信息的分析是通过跨神经系统的错误驱动或匹配不匹配算法完成的。第二，无论任务的认知需求如何，任务相关加工在海马体和纹状体内持续发生。第三，考虑到不同记忆系统之间的高度并行处理，我们认为不同的神经系统可能会有效地竞争对行为表达系统的控制。任何一种神经系统对行为输出的影响强度都可能受到动机、经验或激素状态等因素的调节。(C) 2004爱思唯尔公司版权所有。
A common conceptualization of the organization of memory systems in brain is that different types of memory are mediated by distinct neural systems. Strong support for this view comes from studies that show double (or triple) dissociations between spatial, response, and emotional memories following selective tesions of hippocampus, striatum, and the amygdala. Here, we examine the extent to which hippocampal and striatal neural activity patterns support the multiple memory systems view. A comparison is made between hippocampal and striatal neural correlates with behavior during asymptotic performance of spatial and response maze tasks. Location- (or place), movement, and reward-specific firing patterns were found in both structures regardless of the task demands. Many, but not all, place fields of hippocampal and striatal neurons were similarly affected by changes in the visual and reward context regardless of the cognitive demands. Also, many, but not all, hippocampal and striatal movement-sensitive neurons showed significant changes in their behavioral correlates after a change in visual context, irrespective of cognitive strategy. Similar partial reorganization was observed following manipulations of the reward condition for cells recorded from both structures, again regardless of task. Assuming that representations that persist across context changes reflect learned information, we make the following conclusions. First, the consistent pattern of partial reorganization supports a view that the analysis of spatial, response, and reinforcement information is accomplished via an error-driven, or match-mismatch, algorithm across neural systems. Second, task-relevant processing occurs continuously within hippocampus and striatum regardless of the cognitive demands of the task. Third, given the high degree of parallel processing across allegedly different memory systems, we propose that different neural systems may effectively compete for control of a behavioral expression system. The strength of the influence of any one neural system on behavioral output is likely modulated by factors such as motivation, experience, or hormone status. (C) 2004 Elsevier Inc. All rights reserved.