The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain.
The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain.
复制标题
DOI：
10.1007/s11914-015-0280-1
复制
发表时间：
2015-10
影响因子：
4.3
通讯作者：
Malfait AM
中科院分区：
文献类型：
--
作者：
Miller RE;Tran PB;Obeidat AM;Raghu P;Ishihara S;Miller RJ;Malfait AM
膝关节骨关节炎的特征在于膝关节中所有组织的进行性损伤和重塑。疼痛是膝关节骨关节炎的主要症状。最近的临床和临床前研究揭示了驱动与关节破坏相关的疼痛的机制。在这篇叙述性综述中，我们描述了当前关于骨关节炎进展过程中外周和中枢神经系统变化的知识，并讨论了治疗干预如何缓解疼痛。
Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies shed light on the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous system that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.