Co-infusion of high-dose haploidentical donor cells and CD19-targeted CART cells achieves complete remission, successful donor engraftment and significant CART amplification in advanced ALL

Co-infusion of high-dose haploidentical donor cells and CD19-targeted CART cells achieves complete remission, successful donor engraftment and significant CART amplification in advanced ALL
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高剂量单倍体供体细胞和 CD19 靶向 CART 细胞的共输注可在晚期 ALL 中实现完全缓解、成功的供体植入和显着的 CART 扩增

DOI:
10.1177/1758835920927605
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发表时间:
2020-01
影响因子:
4.9
通讯作者:
Guo Mei
Guo Mei
中科院分区:
医学2区
文献类型:
--
作者:
Yu Changlin;Cai Bo;Wang Yao;Wu Zhiqiang;Hu Kaixun;Sun Qiyun;Qiao Jianhui;Fang Yanhong;Zuo Hongli;Wang Yi;Dong Zheng;Zhang Zechuan;Huang Yajing;Liu Zhiqing;Liu Tieqiang;Ai Huisheng;Han Weidong;Guo Mei

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自体 CD19 靶向嵌合抗原受体修饰 T 细胞 (CD19-CART) 显着改善了晚期 B 细胞急性淋巴细胞白血病 (B-ALL) 患者的预后。然而,同种异体CART细胞的应用和效果仍待进一步研究。
Autologous CD19-targeted chimeric antigen receptor-modified T cells (CD19-CART) remarkably improved the outcome of patients with advanced B-cell acute lymphoblastic leukemia (B-ALL). However, the application and outcomes of allogeneic CART cells is still
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