An iterative fullwave simulation approach to multiple scattering in media with randomly distributed microbubbles.
An iterative fullwave simulation approach to multiple scattering in media with randomly distributed microbubbles.
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DOI：
10.1088/1361-6560/aa6523
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发表时间：
2017-05-21
影响因子：
3.5
通讯作者：
Muller M
中科院分区：
文献类型：
--
作者：
Joshi A;Lindsey BD;Dayton PA;Pinton G;Muller M
超声造影剂 (UCA)，例如微泡，可以增强血液的散射特性，否则血液会出现低回声。由于多重散射理论和非线性微泡响应的复杂性，人们对声场与 UCA 的多重散射相互作用知之甚少。大多数气泡模型将 UCA 的行为描述为悬浮在无限介质中的单个、孤立的微气泡。多个散射模型（例如独立散射近似）可以近似计算低散射体体积分数的相速度和衰减。然而，当前所有模型和模拟方法仅分别描述多重散射和非线性气泡动力学。在这里，我们提出了一种结合了两种现有模型的方法：（1）全波模型，描述非均匀衰减介质中的非线性传播和散射相互作用；（2）保罗-萨卡模型，描述声场和微泡之间的非线性相互作用。这两个模型通过数值求解并结合迭代方法。在计算机中探索了该组合模型的收敛性，其体积浓度为 0.5 × 106 微气泡 ml−1、1% 和 2%。我们的建模方法预测的反向散射通过使用 128 元件线性阵列传感器进行的水箱测量进行了实验验证。基波声场和谐波声场方面表现出极好的一致性。此外，我们的模型正确预测了通过传输测量并通过独立散射近似预测的相速度和衰减。
Ultrasound contrast agents (UCA), such as microbubbles, enhance the scattering properties of blood, which is otherwise hypoechoic. The multiple scattering interactions of the acoustic field with UCA are poorly understood due to the complexity of the multiple scattering theories and the nonlinear microbubble response. The majority of bubble models describe the behavior of UCA as single, isolated microbubbles suspended in infinite medium. Multiple scattering models such as the independent scattering approximation can approximate phase velocity and attenuation for low scatterer volume fractions. However, all current models and simulation approaches only describe multiple scattering and nonlinear bubble dynamics separately. Here we present an approach that combines two existing models: (1) a full-wave model that describes nonlinear propagation and scattering interactions in a heterogeneous attenuating medium and (2) a Paul–Sarkar model that describes the nonlinear interactions between an acoustic field and microbubbles. These two models were solved numerically and combined with an iterative approach. The convergence of this combined model was explored in silico for 0.5 × 106 microbubbles ml−1, 1% and 2% bubble concentration by volume. The backscattering predicted by our modeling approach was verified experimentally with water tank measurements performed with a 128-element linear array transducer. An excellent agreement in terms of the fundamental and harmonic acoustic fields is shown. Additionally, our model correctly predicts the phase velocity and attenuation measured using through transmission and predicted by the independent scattering approximation.
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影响因子：
4.2
作者：
DEJONG, N;CORNET, R;LANCEE, CT
通讯作者：
LANCEE, CT
影响因子：
2.9
作者：
Chatterjee, D;Sarkar, K
通讯作者：
Sarkar, K
模拟脂质涂层微泡封装壳的复杂流变行为，解释壳粘度和弹性的非线性变化
影响因子：
3.5
作者：
Li, Qian;Matula, Thomas J.;Zhang, Dong
通讯作者：
Zhang, Dong
影响因子：
3.2
作者：
KELLER, JB;KOLODNER, II
通讯作者：
KOLODNER, II
影响因子：
6.3
作者：
Appis AW;Tracy MJ;Feinstein SB
通讯作者：
Feinstein SB