Density of CD163+CD11c+ Dendritic Cells Increases and CD103+ Dendritic Cells Decreases in the Coeliac Lesion
Density of CD163+CD11c+ Dendritic Cells Increases and CD103+ Dendritic Cells Decreases in the Coeliac Lesion
复制标题
DOI：
10.1111/j.1365-3083.2011.02549.x
复制
发表时间：
2011-08-01
影响因子：
3.7
通讯作者：
Jahnsen, F. L.
中科院分区：
文献类型：
--
作者：
Beitnes, A. -C. R.;Raki, M.;Jahnsen, F. L.
乳糜泻是一种慢性肠黏膜炎症，由面筋特异性T细胞控制，受疾病相关的人类白细胞抗原-DQ分子的限制。我们之前已经报道过，粘膜CD11c(+)树突状细胞(DC)负责激活腹腔病变中的面筋反应性T细胞。在小鼠中，肠道CD11c(+)DC由几个功能不同的亚群组成。在此，我们报道了正常人十二指肠粘膜中的人类白细胞抗原DQ(+)抗原提呈细胞(APC)可以分为四个亚群：CD163(+)、CD11c(-)巨噬细胞(74%)和CD11c(+)细胞表达CD163(7%)、CD103(11%)或CD1c(13%)。CD103(+)和CD1c(+)DC属于部分重叠的群体，而CD163(+)CD11c(+)APC似乎是一个不同的群体。在病变组织中，CD163(+)CD11c(+)APC密度升高，而CD103(+)和CD1c(+)DC密度降低，提示不同的APC亚群在疾病发病机制中可能发挥不同的作用。
Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten-specific T cells restricted by disease-associated HLA-DQ molecules. We have previously reported that mucosal CD11c(+) dendritic cells (DCs) are responsible for activation of gluten-reactive T cells within the coeliac lesion. In mice, intestinal CD11c(+) DCs comprise several functionally distinct subsets. Here, we report that HLA-DQ(+) antigen-presenting cells (APCs) in normal human duodenal mucosa can be divided into four subsets with striking similarities to those described in mice: CD163(+)CD11c(-) macrophages (74%), and CD11c(+) cells expressing either CD163 (7%), CD103 (11%) or CD1c (13%). CD103(+) and CD1c(+) DCs belonged to partly overlapping populations, whereas CD163(+)CD11c(+) APCs appeared to be a distinct population. In the coeliac lesion, we found increased density of CD163(+)CD11c(+) APCs, whereas the density of CD103(+) and CD1c(+) DCs was decreased, suggesting that distinct subpopulations of APCs in coeliac disease may exert different functions in the pathogenesis.