The chemistry of the in vivo reaction between haemoglobin and various oxides of nitrogen.
The chemistry of the in vivo reaction between haemoglobin and various oxides of nitrogen.
复制标题
血红蛋白和各种氮氧化物之间的体内反应化学。
DOI：
10.1093/bja/39.5.405
复制
发表时间：
1967
影响因子：
9.8
通讯作者：
C. Toothill
中科院分区：
文献类型：
--
作者：
C. Toothill
摘要在暴露于浓度为2%的一氧化氮或二氧化氮的一系列麻醉犬中，发现氧合血红蛋白大量转化为高铁血红蛋白，其中一例发生100%转化。不太明显的变化发生在吸入浓度为0.1-0.5%的范围内。氧气量的减少导致了该系列中一些狗的死亡。亚甲基蓝几乎完全转化为氧合血红蛋白。没有证据表明有其他化合物的形成，如一氧化氮-高铁血红蛋白、一氧化氮-高铁血红蛋白和亚硝酸盐-高铁血红蛋白。
SUMMARY Massive conversion of oxyhaemoglobin to methaemoglobin has been found in a series of anaesthetized dogs exposed to nitric oxide or nitrogen dioxide in concentrations of 2 per cent, 100 per cent conversion occurring in one case. Less marked changes occurred with inspired concentrations in the range 0.1–0.5 per cent. Reduction in oxygen capacity contributed to the death of some dogs in the series. Almost complete reconversion to oxyhaemoglobin was accomplished with methylene blue. There was no evidence for the formation of other compounds such as nitric oxide-haemoglobin, nitric oxide-methaemoglobin and nitrite-methaemoglobin.