Chronic insomnia as a risk factor for developing anxiety and depression
Chronic insomnia as a risk factor for developing anxiety and depression
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DOI：
10.1093/sleep/30.7.873
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发表时间：
2007-07-01
期刊：
影响因子：
5.6
通讯作者：
Dahl, Alv A.
中科院分区：
文献类型：
--
作者：
Neckelmann, Dag;Mykletun, Arnstein;Dahl, Alv A.
研究目的：前瞻性研究失眠与焦虑症和抑郁症的关系，以人群为基础的sample.Design：队列研究的基础上的数据从2个一般健康调查的成年population.Setting：两个一般健康调查的成年人在挪威北特龙德拉格县，HUNT-1在1984 - 6和HUNT-2在1995 - 7进行参与者：在HUNT-1中没有显著焦虑和抑郁的参与者根据两次调查中失眠的存在和不存在进行分类（N = 25，130）。测量和结果：采用医院焦虑抑郁量表对HUNT 2组的焦虑和抑郁进行评定，并进行多因素Logistic回归分析校正年龄、性别、教育、共病抑郁/焦虑和失眠史。HUNT-2中的焦虑障碍与仅HUNT-1中的失眠组（OR 1.6; 95% CI，1.1 - 2.3）、仅HUNT-2中的失眠组（OR 3.4; 95% CI，3.1 - 3.8）以及两项调查中的失眠组（OR 4.9; 95% CI，3.8 - 6.4）显著相关。HUNT-2中的抑郁与仅HUNT-2中的失眠组显著相关（OR 1.8; 95%CI，1.6 - 2.0），但仅HUNT-1中失眠的组或两项调查中失眠的组均不存在。结论：失眠和抑郁症之间只有一种类似状态的联系。除了作为一种状态标记，失眠可能是有患焦虑症风险的个体的特征标志。结果与失眠是焦虑症发展的危险因素一致。
Study Objective: To study prospectively the relations of insomnia to the development of anxiety disorders and depression in a population-based sample.Design: Cohort study based on data from 2 general health surveys of the adult population.Setting: Two general health surveys in the adult population in Nord-Trondelag County of Norway, HUNT-1 performed in 1984-6 and HUNT-2 in 1995-7Participants: Participants without significant anxiety and depression in HUNT-1 were categorized according to the presence and absence of insomnia in the 2 surveys (N=25,130).Measurements and Results: Anxiety disorders and depression in HUNT2 were assessed by the Hospital Anxiety and Depression Scale and analyzed using multivariate logistic regression analysis adjusted for age, gender, education, comorbid depression/anxiety, and history of insomnia. Anxiety disorders in HUNT-2 were significantly associated with the group with insomnia in HUNT-1 only (OR 1.6; 95% Cl, 1.1-2.3), the group with insomnia in HUNT-2 only (OR 3.4; 95% Cl, 3.1-3.8), as well as with the group with insomnia in both surveys (OR 4.9; 95% Cl, 3.8-6.4). Depression in HUNT-2 was significantly associated with the group with insomnia in HUNT-2 only (OR 1.8; 95% Cl, 1.6-2.0), but not with the groups with insomnia in HUNT-1 only or with insomnia in both surveys.Conclusions: Only a state-like association between insomnia and depression was found. In addition to being a state marker, insomnia may be a trait marker for individuals at risk for developing anxiety disorders. Results are consistent with insomnia being a risk factor for the development of anxiety disorders.