Chemical architecture of the posterior striatum in the human brain
Chemical architecture of the posterior striatum in the human brain
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DOI：
10.1007/s00702-007-0803-8
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Gimenez-Amaya, J. M.
中科院分区：
文献类型：
--
作者：
Bernacer, J.;Prensa, L.;Gimenez-Amaya, J. M.
用乙酰胆碱酯酶（AChE）、边缘系统相关膜蛋白（LAMP）、脑啡肽（ENK）、小清蛋白（PV）、钙结合蛋白（CB）和酪氨酸羟化酶（TH）染色的相邻切片，分析了人脑尾状核（CN）（体、回和尾）和壳核（Put）的神经化学组织。除CN尾前三分之二外，所有纹状体区域均可见纹状体。他们是高度免疫反应性（IR）ENK和LAMP，缺乏PV和AChE染色，并包围了一个环的组织与苍白TH-和CB-IR神经元。在Put中，完全没有ENK标记的其他组织环围绕某些纹状体（透明隔）。在CN体，脑回和尾部的一些标记显示梯度和沿着背腹和内外侧轴的异质性。沿着Put的外侧边缘和CN体的背外侧部分，可观察到ENK和LAMP染色密集且PV标记不良的纹状体组织边缘。我们的研究结果说明了化学结构的后纹状体是异质性和略有不同，发现在更前的纹状体。
The neurochemical organization of the posterior caudate nucleus (CN) (body, gyrus and tail) and putamen (Put) was analyzed in the human brain using adjacent sections stained for acetylcholinesterase (AChE), limbic system-associated membrane protein (LAMP), enkephalin (ENK), parvalbumin (PV), calbindin (CB) and tyrosine hydroxylase (TH). Striosomes were visualized in all striatal regions but the anterior two thirds of the CN tail. They were highly immunoreactive (-ir) for ENK and LAMP, devoid of PV and AChE staining, and surrounded by a ring of tissue with pale TH- and CB-ir neuropil. In the Put, other rings of tissue completely free of ENK labeling surrounded certain striosomes (clear septa). In the CN body, gyrus and tail some markers revealed gradients and heterogeneities along the dorsoventral and mediolateral axes. A rim of striatal tissue densely stained for ENK and LAMP and poorly labeled for PV was noticeable along the lateral edge of the Put and the dorsolateral sector of the CN body. Our results illustrate a chemical architecture in the posterior striatum that is heterogeneous and slightly different from that found in the more anterior striatum.