Comparison of the stability of Glycoprotein Acetyls and high sensitivity C-reactive protein as markers of chronic inflammation
Comparison of the stability of Glycoprotein Acetyls and high sensitivity C-reactive protein as markers of chronic inflammation
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糖蛋白乙酰基和高敏 C 反应蛋白作为慢性炎症标志物的稳定性比较
DOI：
10.1101/2023.03.02.23286349
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Crick D
中科院分区：
文献类型：
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作者：
Crick D
有人认为糖蛋白乙酰基（GlycA）比高敏C反应蛋白（hsCRP）更能反映慢性炎症，但儿科/生命过程数据很少。使用来自雅芳父母和儿童纵向研究（ALSPAC）和英国生物银行的数据，我们比较了GlycA和hsCRP的短期（数周）和长期（数年）相关性，GlycA和hsCRP之间的横截面相关性，以及促炎风险因素与GlycA和hsCRP在整个生命过程中的相关性。GlycA在15年时显示出较高的短期（周）稳定性（r= 0.75; 95% CI = 0.56，0.94），18年（r= 0.74; 0.64，0.85），24年（r= 0.74; 0.51，0.98）和48年（r= 0.82 0.76，0.86），这与24年时hsCRP的短期稳定性相当。GlycA的长期稳定性为中等，例如15 - 18年之间sr = 0.52; 0.47，0.56和15 - 24年之间sr = 0.37; 0.31，0.44。这些大于hsCRP的等效相关性。GlycA和同时测量的hsCRP在所有年龄段均中度相关，例如15岁（r= 0.44; 0.40，0.48）和18岁（r= 0.55; 0.51，0.59）。我们发现已知的促炎因子和炎症性疾病与GlycA和hsCRP有类似的关联。例如，BMI与GlycA（GlycA的平均差异/BMI的标准差变化= 0.08; 95% CI = 0.07，0.10）和hsCRP（0.10; 0.08，0.11）呈正相关。这项研究表明，GlycA的长期稳定性高于hsCRP，但促炎因子与GlycA和hsCRP的相关性大致相似。
It has been suggested that glycoprotein acetyls (GlycA) better reflects chronic inflammation than high sensitivity C‐reactive protein (hsCRP), but paediatric/life‐course data are sparse. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK Biobank, we compared short‐ (over weeks) and long‐term (over years) correlations of GlycA and hsCRP, cross‐sectional correlations between GlycA and hsCRP, and associations of pro‐inflammatory risk factors with GlycA and hsCRP across the life‐course. GlycA showed high short‐term (weeks) stability at 15 years (r= 0.75; 95% CI = 0.56, 0.94), 18 years (r= 0.74; 0.64, 0.85), 24 years (r= 0.74; 0.51, 0.98) and 48 years (r= 0.82 0.76, 0.86) and this was comparable to the short‐term stability of hsCRP at 24 years. GlycA stability was moderate over the long‐term, for example between 15 and 18 yearsr= 0.52; 0.47, 0.56 and between 15 and 24 yearsr= 0.37; 0.31, 0.44. These were larger than equivalent correlations of hsCRP. GlycA and concurrently measured hsCRP were moderately correlated at all ages, for example at 15 years (r= 0.44; 0.40, 0.48) and at 18 years (r= 0.55; 0.51, 0.59). We found similar associations of known proinflammatory factors and inflammatory diseases with GlycA and hsCRP. For example, BMI was positively associated with GlycA (mean difference in GlycA per standard deviation change in BMI = 0.08; 95% CI = 0.07, 0.10) and hsCRP (0.10; 0.08, 0.11). This study showed that GlycA has greater long‐term stability than hsCRP, however associations of proinflammatory factors with GlycA and hsCRP were broadly similar.