Applications of metabolomics in cancer research.
Applications of metabolomics in cancer research.
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DOI：
10.4103/1477-3163.113622
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发表时间：
2013
影响因子：
--
通讯作者：
Styczynski MP
中科院分区：
文献类型：
--
作者：
Vermeersch KA;Styczynski MP
几乎在世纪以前，人们首次发现了癌症的代谢变化。虽然癌症的遗传基础从那时起就主导了其研究，但代谢改变最近被认为是癌症的一个关键标志，以代谢为重点的研究再次受到关注。新兴的代谢组学领域-试图描述细胞或生物系统内的所有代谢物-现在正被用于在全系统范围内分析癌症代谢，描绘改变的途径及其相互作用的广泛图景。虽然癌症代谢组学研究的很大一部分集中在寻找诊断生物标志物上，但代谢组学也被用于获得对癌症和致癌作用的更基本的机制见解。代谢组学的应用也出现在肿瘤分期和疗效评估等领域。本文综述了代谢组学在癌症研究中的贡献，并提出了该领域目前面临的挑战和潜在的未来发展方向。
The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer and metabolism-focused research has received renewed attention. The emerging field of metabolomics – which attempts to profile all metabolites within a cell or biological system – is now being used to analyze cancer metabolism on a system-wide scale, painting a broad picture of the altered pathways and their interactions with each other. While a large fraction of cancer metabolomics research is focused on finding diagnostic biomarkers, metabolomics is also being used to obtain more fundamental mechanistic insight into cancer and carcinogenesis. Applications of metabolomics are also emerging in areas such as tumor staging and assessment of treatment efficacy. This review summarizes contributions that metabolomics has made in cancer research and presents the current challenges and potential future directions within the field.