The University of Minnesota biocatalysis/biodegradation Database: specialized metabolism for functional genomics
The University of Minnesota biocatalysis/biodegradation Database: specialized metabolism for functional genomics
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DOI：
10.1093/nar/27.1.373
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发表时间：
1999-01-01
影响因子：
14.9
通讯作者：
Wackett, LP
中科院分区：
文献类型：
--
作者：
Ellis, LBM;Hershberger, CD;Wackett, LP
明尼苏达大学生物催化/生物降解数据库(UM-BBD，http://www.labmed.umn.edu/umbbd/index.html))于1995年首次在网上提供，以提供关于有机化合物，特别是人类产生的化合物的微生物生物催化反应和生物降解途径的信息。它的目标是成为生物降解的代表性数据库，跨越已知的微生物代谢途径、有机官能团和发生生物降解的环境条件的多样性，该数据库可用于加强对基础生物化学、导致特殊化学制造的生物催化以及环境污染物的生物降解的了解，它也是功能基因组学的资源，因为它包含中间代谢数据库中找不到的涉及专门化新陈代谢的酶和基因的信息，因此可以帮助分配与这些不太常见的基因同源的基因的功能，具有关于>的信息；它将成为预测其不包含的化合物的微生物生物降解途径的资源，这一过程是对预测新类别微生物基因功能的补充。
The University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD, http://www.labmed.umn.edu/umbbd/index.html) first became available on the web in 1995 to provide information on microbial biocatalytic reactions of, and biodegradation pathways for, organic chemical compounds, especially those produced by man. Its goal is to become a representative database of biodegradation, spanning the diversity of known microbial metabolic routes, organic functional groups, and environmental conditions under which biodegradation occurs, The database can be used to enhance understanding of basic biochemistry, biocatalysis leading to speciality chemical manufacture, and biodegradation of environmental pollutants, It is also a resource for functional genomics, since it contains information on enzymes and genes involved in specialized metabolism not found in intermediary metabolism databases, and thus can assist in assigning functions to genes homologous to such less common genes, With information on >400 reactions and compounds, it is poised to become a resource for prediction of microbial biodegradation pathways for compounds it does not contain, a process complementary to predicting the functions of new classes of microbial genes.