MICROSPHERES FOR TARGETING DRUGS TO SPECIFIC BODY SITES
MICROSPHERES FOR TARGETING DRUGS TO SPECIFIC BODY SITES
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DOI：
10.1016/0168-3659(93)90175-5
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发表时间：
1993-05-01
影响因子：
10.8
通讯作者：
DUNN, SE
中科院分区：
文献类型：
--
作者：
DAVIS, SS;ILLUM, L;DUNN, SE
乳液、脂质体和微球形式的微粒可用于多种医学应用，不仅包括药物递送，还包括疫苗施用和用作诊断剂。本报告将集中在肠胃外管理和应用的概念，粒子工程设计的载体，将提供网站的具体交付，即药物靶向。这些概念包括颗粒尺寸、表面电荷、表面疏水性的故意修改以及胶体科学原理的应用，包括空间稳定。具有适当表面特性和粒度的颗粒可用于静脉内递送，以靶向肺、肝、脾、全身循环或骨髓。其中前两个现在被认为是有点琐碎的性质[11]。它们分别涉及网状内皮系统的过滤和识别过程，并可用于在肺和肝区域提供良好的颗粒摄取。相比之下，目标-
Microparticles in the form of emulsions, liposomes and microspheres have utility for a variety of medical applications to include not only drug delivery but also vaccine administration and use as diagnostic agents. This presentation will concentrate on parenteral administration and the application of concepts of particle engineering for the design of carriers that will provide site specific delivery, ie, drug targeting. These concepts include the deliberate modification of particle size, surface charge, surface hydrophobicity as well as the application of principles from colloid science, to include steric stabilization. Particles with the appropriate surface characteristics and particle size can be used for intravenous delivery in order to target the lung, liver, spleen, the general circulation or the bone marrow. The first two of these are now considered to be somewhat trivial in nature [11. They involve processes of filtration and recognition by the reticuloendothelial system, respectively, and can be exploited to provide good uptake of particulates in the lung and liver regions. In contrast, target-