Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs.
Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs.
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DOI：
10.1517/17425247.2011.571672
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发表时间：
2011-06
影响因子：
6.6
通讯作者：
Bhattacharya A
中科院分区：
文献类型：
--
作者：
Bhattacharya A
尽管取得了进展，但实体恶性肿瘤的化疗反应仍然有限。虽然在联合化疗中使用抗血管生成药物的初步结果表明治疗反应增强，但最近的数据表明，存活的癌症不仅能够克服治疗，而且实际上能够适应更具侵袭性的转移表型。因此，选择一种不太可能导致肿瘤复发的抗血管生成药物是未来抗血管生成药物在联合治疗中成功的关键。针对目前临床上广泛使用的抗血管生成药物，本文讨论了使用有机硒（Se）化合物（如甲基硒半胱氨酸（MSC））的可能益处。MSC是一种耐受性好、用途广泛、经济实惠的抗血管生成药物，是哺乳动物生理学的一部分。它下调多个关键的上游肿瘤生存标志物，并在给定的全身剂量的抗癌药物下增强肿瘤药物传递，同时保护正常组织免受细胞毒性副作用的影响。进一步的临床试验，特别是在低分化癌症中，是有必要的。
Despite progress, chemotherapeutic response in solid malignancies has remained limited. While initial results of the use of antiangiogenic agents in combination chemotherapy indicated an enhanced therapeutic response, recent data indicates that the surviving cancer is not only able to surmount therapy, but is actually able to adapt a more aggressive metastatic phenotype. Thus, selecting an antiangiogenic agent that is less likely to lead to tumor resurgence is a key to future therapeutic success of antiangiogenic agents, in a combinatorial setting. Against the broad spectrum of currently used antiangiogenic agents in the clinic, the putative benefits of the use of organo selenium (Se) compounds, such as methylselenocysteine (MSC), are discussed in this reiew. MSC, being part of the mammalian physiology, is a well tolerated, versatile and economical antiangiogenic agent. It down regulates multiple key upstream tumor survival markers, and enhances tumor drug delivery, at a given systemic dose of an anticancer agent, while protecting normal tissue from cytotoxic adverse effects. Further clinical trials, especially in poorly differentiated cancers, are warranted.
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影响因子：
11.5
作者：
Bhattacharya, A;T贸th, K;Rustum, YM
通讯作者：
Rustum, YM
影响因子：
3.4
作者：
Fakih, Marwan;Cao, Shousong;Rustum, Youcef M
通讯作者：
Rustum, Youcef M
影响因子：
82.9
作者：
Ceradini, DJ;Kulkarni, AR;Gurtner, GC
通讯作者：
Gurtner, GC
DOI：
10.1038/nrc2442
发表时间：
2008-08
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Corcoran, N. M.;Hovens, C. M.;Michael, M.;Rosenthal, M. A.;Costello, A. J.
通讯作者：
Costello, A. J.