An Investigation into the Effect of Fine Lactose Particles on the Fluidization Behaviour and Aerosolization Performance of Carrier-Based Dry Powder Inhaler Formulations
An Investigation into the Effect of Fine Lactose Particles on the Fluidization Behaviour and Aerosolization Performance of Carrier-Based Dry Powder Inhaler Formulations
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DOI：
10.1208/s12249-014-0119-6
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发表时间：
2014-08-01
影响因子：
3.3
通讯作者：
Price, Robert
中科院分区：
文献类型：
--
作者：
Kinnunen, Hanne;Hebbink, Gerald;Price, Robert
研究了研磨和微粉化乳糖细粉对干粉吸入器（DPI）制剂的流化和体外雾化特性的影响，并评估了静态和动态方法用于表征这些混合物的一般粉末流动特性的适用性。通过以2.5、5、10和20重量%浓度添加不同的乳糖细粉（Lactohale r（LH）300、230和210）与粗载体乳糖（Lactohale 100）来制备乳糖载体预混物。使用Freeman Technology FT 4和Schulze RST-XS环形剪切试验机表征乳糖预混物的粉末流动性能。在使用Freeman FT 4流变仪测量的基本流动能（BFENE）和在Schulze RST-XS上测量的流动性数值（ff（c））之间发现强相关性。这些数据表明，静态和动态方法都适用于表征乳糖载体的一般粉末流动特性。细粉浓度的增加对应于标准化流化能量（FENklag）的增加。包含乳糖的细颗粒导致显著（p
The effect of milled and micronized lactose fines on the fluidization and in vitro aerosolization properties of dry powder inhaler (DPI) formulations was investigated, and the suitability of static and dynamic methods for characterizing general powder flow properties of these blends was assessed. Lactose carrier pre-blends were prepared by adding different lactose fines (Lactohale r (LH) 300, 230 and 210) with coarse carrier lactose (Lactohale100) at 2.5, 5, 10 and 20 wt% concentrations. Powder flow properties of lactose pre-blends were characterized using the Freeman Technology FT4 and Schulze RST-XS ring shear tester. A strong correlation was found between the basic flow energy (BFENorm) measured using the Freeman FT4 Rheometer and the flowability number (ff(c)) measured on Schulze RST-XS. These data indicate that both static and dynamic methods are suitable for characterizing general powder flow properties of lactose carriers. Increasing concentration of fines corresponded with an increase in the normalized fluidization energy (FENorm). The inclusion of fine particles of lactose resulted in a significant (p