Brain 18F-FDG PET Imaging in the Differential Diagnosis of Parkinsonism
Brain 18F-FDG PET Imaging in the Differential Diagnosis of Parkinsonism
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DOI：
10.1097/rlu.0000000000000315
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发表时间：
2014-03-01
影响因子：
10.6
通讯作者：
Kapucu, Lutfiye Ozlem
中科院分区：
文献类型：
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作者：
Akdemir, Umit Ozgur;Tokcaer, Ayse Bora;Kapucu, Lutfiye Ozlem
目的：本研究的目的是评估脑部 F-18-FDG PET 成像在帕金森症鉴别诊断中的作用，并将脑部代谢结果与患者的临床表现相关联。方法：使用 NeuroQ 软件对 21 名帕金森症患者的脑部 F-18-FDG PET 图像进行视觉和定量评估，并在这些患者中建立最终的临床诊断。结果：最终临床诊断为 7 例特发性帕金森病，多系统萎缩(MSA) 7 例，进行性核上性麻痹 (PSP) 4 例，皮质基底节变性 2 例，路易体病 1 例。大多数患者的额叶和顶颞区均观察到不对称的皮质代谢减退。 21 名患者中有 15 名基底神经节受累，MSA 患者为双侧，特发性帕金森病和 PSP 患者为单侧。 4 名 PSP 患者和 1 名皮质基底节变性患者存在丘脑代谢低下。在 4 名 MSA 患者中观察到小脑代谢低下。基底节受累患者的统一帕金森病评定量表运动和运动迟缓评分较高。结论：皮层下核和小脑的脑 F-18-FDG PET 检查发现有助于帕金森病患者的鉴别诊断。大脑皮质和基底神经节代谢低下的程度与临床表现和严重程度相关。
Aim: The aims in this study were to evaluate the role of brain F-18-FDG PET imaging in differential diagnosis of parkinsonism and to correlate brain metabolism findings with patients' clinical findings.Methods: Brain F-18-FDG PET images were evaluated both visually and quantitatively using the NeuroQ software in 21 parkinsonism patients in whom final clinical diagnoses were established.Results: Final clinical diagnoses were idiopathic Parkinson disease in 7, multisystem atrophy (MSA) in 7, progressive supranuclear palsy (PSP) in 4, corticobasal degeneration in 2, and Lewy body disease in 1 patient. Asymmetrical cortical hypometabolism was observed in most of the patients in frontal and parietotemporal regions. Fifteen of 21 patients had basal ganglia involvement, which was bilateral in patients with MSA and more frequently unilateral in patients with idiopathic Parkinson disease and PSP. Four patients with PSP and 1 patient with corticobasal degeneration had thalamic hypometabolism. Cerebellar hypometabolism was observed in 4 patients with MSA. The Unified Parkinson Disease Rating Scale motor and bradykinesia scores were higher in patients with basal ganglia involvement.Conclusions: Brain F-18-FDG PET findings in subcortical nuclei and cerebellum were found to be useful in differential diagnosis of patients with parkinsonism. The extent of cerebral cortical and basal ganglia hypometabolism showed correlation with the presentation and severity of clinical findings.