LOW-FREQUENCY ACTIVATION OF THE NMDA RECEPTOR SYSTEM CAN PREVENT THE INDUCTION OF LTP
LOW-FREQUENCY ACTIVATION OF THE NMDA RECEPTOR SYSTEM CAN PREVENT THE INDUCTION OF LTP
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DOI：
10.1016/0304-3940(89)90038-4
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发表时间：
1989-10-23
影响因子：
2.5
通讯作者：
COLLINGRIDGE, GL
中科院分区：
文献类型：
--
作者：
COAN, EJ;IRVING, AJ;COLLINGRIDGE, GL
在大鼠海马脑片浸泡在无镁介质强直刺激一般未能引起长时程增强（LTP）的Schaffer侧支连合通路。然而，LTP可以诱导在相同的切片后，重新引入1 mM Mg 2+。在无Mg ~（2+）培养基中。在20 μ M D-2-氨基-5-膦酰基戊酸酯（APV）存在下可诱导LTP，但通过将APV浓度增加至200 μ M而被阻断。较低浓度的APV足以防止N-甲基-D-天冬氨酸（NMDA）受体在低频传输过程中的激活，但在破伤风过程中则不然。因此，我们认为，某些类型的NMDA受体系统的激活可以禁用LTP诱导机制。
In rat hippocampal slices bathed in Mg2+-free medium tetanic stimulation generally failed to elicit long-term potentiation (LTP) in the Schaffer collateral-commissural pathway. However, LTP could be induced in the same slices following the re-introduction of 1 mM Mg2+. In Mg2+-free medium. LTP could be induced in the presence of 20 .mu.M D-2-amino-5-phosphonovalerate (APV) but was blocked by increasing the APV concentration to 200 .mu.M. The lower concentration of APV is sufficient to prevent N-methyl-D-aspartate (NMDA) receptor activation during low-frequency transmission but not during the tetanus. We suggest therefore, that certain types of activation of the NMDA receptor system can disable the LTP induction mechanism.