Barley stripe mosaic virus γb interacts with glycolate oxidase and inhibits peroxisomal ROS production to facilitate virus infection
Barley stripe mosaic virus γb interacts with glycolate oxidase and inhibits peroxisomal ROS production to facilitate virus infection
复制标题
大麦条纹花叶病毒γb与乙醇酸氧化酶相互作用并抑制过氧化物酶体ROS产生以促进病毒感染
DOI：
10.1016/j.molp.2017.10.007
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发表时间：
2018
期刊：
影响因子：
27.5
通讯作者：
Li Dawei
中科院分区：
文献类型：
--
作者：
Yang Meng;Li Zhenggang;Zhang Kun;Zhang Xuan;Zhang Yongliang;Wang Xianbing;Han Chenggui;Yu Jialin;Xu Kai;Li Dawei
植物自然会受到包括病毒、细菌和真菌在内的多种病原体的感染，并进化出许多策略来规避病原胁迫。过氧化氢(H_2O_2)或超氧阴离子(O_2±)等活性氧物种(ROS)的快速产生是细胞对病原体感染最早的反应之一(Bolwell和Wojtaszek，1997)。植物受侵染后，由NADPH氧化酶(也称为呼吸爆发氧化酶同系物，RBOH)诱导ROS爆发，催化O2转化为超氧化物(O2±)。另一种产生ROS的途径是由乙醇酸氧化酶(Gox)介导的。GOX是一种含有黄素单核苷酸(FMN)的酶，存在于植物和哺乳动物的过氧化体中，催化乙醇酸或其衍生物的氧化，并在光呼吸过程中产生乙醛酸和过氧化氢。RBOH或Gox衍生的ROS已被证明参与植物抵御细菌病原体的防御(Rojas和Mysore，2012)。植物正链RNA病毒是专性寄生，其繁殖依赖于宿主蛋白因子和宿主代谢产物(Hyodo等人，2017；Xu和Nagy，2017)。尽管有证据表明ROS爆发与成功的植物病毒侵染和疾病发展有关(Dıaz-Vivancos等人，2008年)，但ROS影响病毒侵染的机制尚未完全阐明。
Plants are naturally infected by a wide range of pathogens including viruses, bacteria, and fungi, and have evolved many strategies to circumvent pathogenic stresses. Rapid generation of reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) or superoxide anions (O2 À) are one of the earliest cellular responses against pathogen infections (Bolwell and Wojtaszek, 1997). After infection, an ROS burst in plants is induced by NADPH oxidase (also known as respiratory burst oxidase homologs, RBOH), which catalyzes the conversion of O2 to superoxide (O2 À). An alternative ROS-producing pathway is mediated by glycolate oxidase (GOX). GOX is a flavin mononucleotide (FMN)-containing enzyme found in plant and mammalian peroxisomes that catalyzes oxidation of glycolate or its derivatives and generates glyoxylate and H2O2 during photorespiration. Either RBOH-or GOX-derived ROS have been shown to be involved in plant defenses against bacterial pathogens (Rojas and Mysore, 2012).Plant positive-strand RNA viruses are obligate parasites whose multiplication depends on host protein factors as well as host metabolites (Hyodo et al., 2017; Xu and Nagy, 2017). Although there is some evidence suggesting that ROS bursts are correlated with successful plant virus infection and disease development (Dıaz-Vivancos et al., 2008), the mechanisms by which ROS affect virus infection have not been fully elucidated.