S-Nitrosylation Regulates Cell Survival and Death in the Central Nervous System.
S-Nitrosylation Regulates Cell Survival and Death in the Central Nervous System.
复制标题
S-亚硝基化调节中枢神经系统的细胞存活和死亡。
DOI：
10.1007/s11064-017-2303-z
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Furukawa A.
中科院分区：
文献类型：
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作者：
Koriyama Y;Furukawa A.
一氧化氮（NO）由一氧化氮合酶产生，是一种重要的细胞信号分子，对神经元死亡、神经元存活、突触可塑性和血管稳态等生理功能起着至关重要的作用。这种可扩散的气体化合物在许多细胞间通信和/或细胞信号传导途径中起效应物或第二信使的作用。蛋白质s -亚硝基化是一种翻译后修饰，涉及NO基团与靶蛋白上选择的半胱氨酸残基的硫醇侧链的共价连接。这一过程被认为对中枢神经系统（CNS）细胞死亡、细胞存活和基因表达的调控非常重要。然而，关于蛋白质s -亚硝基化在中枢神经系统疾病中的作用的报道很少。在这里，我们简要回顾了s -亚硝基化的具体例子，特别强调了它在神经元细胞死亡和存活中的功能。了解蛋白质s -亚硝基化在神经退行性/神经保护事件中的作用和机制可能为神经退行性疾病中拯救神经元提供新的治疗策略。
Nitric oxide (NO), which is produced from nitric oxide synthase, is an important cell signaling molecule that is crucial for many physiological functions such as neuronal death, neuronal survival, synaptic plasticity, and vascular homeostasis. This diffusible gaseous compound functions as an effector or second messenger in many intercellular communications and/or cell signaling pathways. ProteinS-nitrosylation is a posttranslational modification that involves the covalent attachment of an NO group to the thiol side chain of select cysteine residues on target proteins. This process is thought to be very important for the regulation of cell death, cell survival, and gene expression in the central nervous system (CNS). However, there have been few reports on the role of proteinS-nitrosylation in CNS disorders. Here, we briefly review specific examples ofS-nitrosylation, with particular emphasis on its functions in neuronal cell death and survival. An understanding of the role and mechanisms underlying the effects of proteinS-nitrosylation on neurodegenerative/neuroprotective events may reveal a novel therapeutic strategy for rescuing neurons in neurodegenerative diseases.