Myocardial contraction fraction: A volumetric index of myocardial shortening by freehand three-dimensional echocardiography
Myocardial contraction fraction: A volumetric index of myocardial shortening by freehand three-dimensional echocardiography
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DOI：
10.1016/s0735-1097(02)01944-7
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发表时间：
2002-07-17
影响因子：
24
通讯作者：
Maurer, MS
中科院分区：
文献类型：
--
作者：
King, DL;Coffin, LE;Maurer, MS
目的探讨心肌收缩分数（MCF）作为高血压肥厚患者心肌短轴缩短的指标，高血压肥大患者中有相当比例的左心室（LV）“正常”或“保留”通过常规超声心动图测量收缩功能，而当通过二维超声心动图中壁缩短分数（MWSF）测量时，其收缩功能被抑制。缺乏类似于MWSF的心肌缩短的三维超声心动图测量。我们描述了心肌缩短的容积测量，MCF，作为每搏输出量（SV）与心肌容积（MV）的比值，并假设它可能有助于比较不同程度和类型的肥厚患者的心肌性能。方法我们比较了使用徒手三维超声心动图重建LV的MCF和常规LV功能测量结果：17例病理性高血压肥厚伴心力衰竭症状且EF正常者、41例生理性高血压肥厚运动员和80例正常人EF均在正常范围内。高血压性肥厚患者的MCF低于正常人（0.33 ± 0.05 vs. 0.44 ± 0.07，p
Objectives This study sought to evaluate myocardial contraction fraction (MCF) as an index of myocardial shortening by comparison to conventional shortening indices in patients with hypertensive hypertrophy, athletes with physiologic hypertrophy and sedentary normal adult subjects.Background A significant percentage of patients with hypertensive hypertrophy have "normal" or "preserved" left ventricular (LV) systolic function by conventional echocardiographic measures whereas their systolic function is depressed when measured by the two-dimensional echocardiographic mid-wall shortening fraction (MWSF). A three-dimensional echocardiographic measure of myocardial shortening analogous to MWSF has been lacking. We describe a volumetric measure of myocardial shortening, the MCF, as the ratio of stroke volume (SV) to myocardial volume (MV), and hypothesize that it may be useful to compare myocardial performance in patients with different degrees and types of hypertrophy.Methods We compared the MCF using freehand three-dimensional echocardiographic reconstruction of the LV to conventional measures of LV function (election fraction [EF], endocardial shortening fraction [SF] and MWSF) in subjects with pathologic hypertensive hypertrophy, heart failure symptoms and preserved EF (n=17), athletes with physiologic hypertrophy (n=41) and normal sedentary adults (n=80).Results The EF was in the normal range for all three groups. The MCF was lower in hypertensive hypertrophy compared with normal subjects (0.33+/-0.05 vs. 0.44+/-0.07, p