Posterior vitreous detachment and macular microvasculature in the elderly
Posterior vitreous detachment and macular microvasculature in the elderly
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DOI：
10.1371/journal.pone.0231351
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发表时间：
2020-04
期刊：
影响因子：
3.7
通讯作者：
Taku Toyama;H. Kawai;T. Shiraya;F. Araki;K. Sugimoto;Yohei Hashimoto;S. Kato;J. Numaga;Yutaka Watanabe;H. Hirano;Y. Fujiwara;K. Ihara;Hunkyung Kim;S. Obuchi;T. Ueta
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文献类型：
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作者：
Taku Toyama;H. Kawai;T. Shiraya;F. Araki;K. Sugimoto;Yohei Hashimoto;S. Kato;J. Numaga;Yutaka Watanabe;H. Hirano;Y. Fujiwara;K. Ihara;Hunkyung Kim;S. Obuchi;T. Ueta
目的 探讨老年人玻璃体后脱离（PVD）不同阶段与黄斑微血管的关系。方法对 322 名年龄 ≥ 65 岁的参与者的 490 只眼睛的扫频光学相干断层扫描 (OCT)、OCT 血管造影和彩色眼底图像进行评估。使用增强玻璃体可视化模式将PVD分类为无明显PVD（0/1级）、中央凹和视盘玻璃体粘连（2级）、视盘粘连（3级）或完全PVD（4级）。分析了微血管参数，包括中心凹无血管区 (FAZ) 和血管密度 (VD)，以确定它们与完全 PVD 的关系。此外，还讨论了 PVD 与中央视网膜厚度 (CRT) 之间的关联。结果 总体而言，80、31、31 和 349 只眼睛分别被分为 0/1、2、3 和 4 阶段。使用多变量混合效应模型，与 0-3 期相比，第 4 期的平均浅表 FAZ 面积较小（0.29 vs. 0.32 mm2；P = 0.014），并且与 0-3 期相比，第 4 期的平均浅表 VD 较低（34.96% vs. 35.24%；P = 0.0089）。然而，PVD 与深部黄斑微血管参数或 CRT 没有显着相关性。结论 完全PVD与浅层黄斑微血管中较小的FAZ面积和较低的VD相关，但与中央视网膜厚度无关。
Purpose To investigate the association between different stages of posterior vitreous detachment (PVD) and macular microvasculature in the elderly. Methods Swept-source optical coherence tomography (OCT), OCT angiography, and color fundus images of 490 eyes without retinal pathologies of 322 participants aged ≥65 years were evaluated. PVD was classified using enhanced vitreous visualization mode as no apparent PVD (stage 0/1), vitreous adhesions at the fovea and optic disc (stage 2), adhesion at the optic disc (stage 3), or complete PVD (stage 4). Microvascular parameters, including foveal avascular zone (FAZ) and vessel density (VD), were analyzed for their associations with complete PVD. Additionally, the association between PVD and central retinal thickness (CRT) was also addressed. Results Overall, 80, 31, 31, and 349 eyes were categorized into stages 0/1, 2, 3, and 4, respectively. Using multivariate mixed-effects model, the mean superficial FAZ area was smaller in stage 4 compared with stages 0–3 (0.29 vs. 0.32 mm2; P = 0.014), and the mean superficial VD was lower in stage 4 compared with stages 0–3 (34.96% vs. 35.24%; P = 0.0089). However, PVD was not significantly associated with deep macular microvascular parameters or CRT. Conclusions Complete PVD was associated with smaller FAZ area and lower VD in superficial macular microvasculature, while it was not associated with central retinal thickness.