Elastic properties of organ of Corti tissues from point-stiffness measurement and inverse analysis.
Elastic properties of organ of Corti tissues from point-stiffness measurement and inverse analysis.
复制标题
点刚度测量和反演分析的柯蒂组织器官的弹性特性。
DOI：
10.1016/j.jbiomech.2014.02.025
复制
发表时间：
2014
影响因子：
2.4
通讯作者：
Mountain,DC
中科院分区：
文献类型：
--
作者：
Zagadou,BF;Barbone,PE;Mountain,DC
We describe a method to use point-stiffness (PtSt) measurements, i.e., indentation measurements, to obtain elastic moduli of different organ of Corti (OC) tissues. A detailed finite element (FE) model of the OC is used to account for geometric effects in the indentation measurements. We also present a sensitivity analysis, performed within a Bayesian estimation framework, that can be used to improve experimental design. The sensitivity analysis shows that the basilar membrane (BM) PtSt is most sensitive to changes in the BM properties and to changes in the pillar cells (PC) properties. This result suggests that the BM and the PC dominate the macromechanics of the OC. The most likely values of the Young׳s modulus predicted for the middle turn for the BM arcuate, BM pectinate, and the PC are found to be 935 KPa (range 640–1360 KPa), 300 KPa (range 190–460 KPa), and 3 GPa (range 1–9 GPa), respectively.
