The spectrum of movement disorders in children with anti-NMDA receptor encephalitis
The spectrum of movement disorders in children with anti-NMDA receptor encephalitis
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DOI：
10.1002/mds.25354
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发表时间：
2013-04-01
影响因子：
8.6
通讯作者：
Jankovic, Joseph
中科院分区：
文献类型：
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作者：
Baizabal-Carvallo, Jose Fidel;Stocco, Amber;Jankovic, Joseph
运动障碍是常见的，但很难在抗N-甲基-d-天冬氨酸受体（NMDAR）脑炎患者的特点。方法对抗NMDAR脑炎患儿进行详细检查后，对运动障碍的现象学进行表征。结果我们研究了9名儿童（5名女性），年龄314岁，确诊为抗NMDAR脑炎。所有患者均出现至少1种运动障碍，包括舞蹈病（n=4）、刻板运动（n=4）、共济失调（n=3）、肢体肌张力障碍（n = 2）、肢体肌节律（n = 2）、口下颌肌张力障碍（n =2）、面部肌节律、眼睑痉挛、角弓反张、手足徐动症和震颤（各n=1）。在这些患者中的6例中观察到不止一种运动障碍。在所有接受免疫治疗的患者中观察到异常运动的消退; 1名患者在丁苯那嗪治疗后得到改善。结论在抗NMDAR脑炎患儿中可观察到多种运动障碍，且常合并。患者通常出现不止一种运动障碍。(c)2013年运动障碍协会
Background Movement disorders are frequent but difficult to characterize in patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Methods The phenomenology of movement disorders was characterized after a detailed examination of children with anti-NMDAR-encephalitis. Results We studied 9 children (5 females), ages 314 years, with confirmed anti-NMDAR-encephalitis. All patients presented with at least 1 movement disorder, including chorea (n=4), stereotypic movements (n=4), ataxia (n=3), limb dystonia (n=2), limb myorhythmia (n=2), oromandibular dystonia (n=2), facial myorhythmia, blepharospasm, opisthotonus, athetosis, and tremor (n=1, each). More than a single movement disorder was observed in 6 of these patients. Resolution of the abnormal movements was observed in all patients with immunotherapy; 1 patient improved with tetrabenazine. Conclusions A wide variety of movement disorders, often in combination, can be observed in children with anti-NMDAR encephalitis. Patients commonly present with more than a single movement disorder. (c) 2013 Movement Disorder Society