Male infertility in reciprocal translocation carriers: the sex body affair
Male infertility in reciprocal translocation carriers: the sex body affair
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DOI：
10.1159/000086908
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发表时间：
2005-01-01
影响因子：
1.7
通讯作者：
Martin, RH
中科院分区：
文献类型：
--
作者：
Oliver-Bonet, M;Ko, E;Martin, RH
以前的报道将染色体重组和精子发生障碍联系起来。在这种情况下，人们早就知道相互易位携带者更可能在减数分裂过程中出现异常，包括育性失败。也有人提出，这种生育失败可能是易位的染色体和性体之间的关联的结果。在这项工作中，我们回顾了不同的假设解释减数分裂失败，在这些运营商，并提出了一个模型，涉及减数分裂异常与性体易位协会和不同的检查点，是已知的减数分裂过程中操作。
Previous reports have linked chromosomal reorganization and spermatogenic failure. In this context, it has long been known that reciprocal translocation carriers are more likely to have anomalies in the meiotic process, including fertility failures. It has also been proposed that this fertility failure may be a consequence of an association between the translocated chromosomes and the sex body. In this work, we review different hypotheses explaining meiotic failure in these carriers, and propose a model that relates meiotic abnormalities with both sex body-translocation association and different checkpoints that are known to operate during meiosis.