Influence of hemicholinium (HC-3) on morphine analgesia, tolerance, physical dependence and on brain acetylcholine.
Influence of hemicholinium (HC-3) on morphine analgesia, tolerance, physical dependence and on brain acetylcholine.
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半胆碱 (HC-3) 对吗啡镇痛、耐受性、身体依赖性和脑乙酰胆碱的影响。
DOI：
10.1016/0014-2999(74)90024-7
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发表时间：
1974
影响因子：
5
通讯作者：
E. Way
中科院分区：
文献类型：
--
作者：
H. Bhargava;S. Chan;E. Way
HC-3脑内给药的剂量，减少脑乙酰胆碱（ACh），而没有任何变化的胆碱（Ch）水平拮抗吗啡抗伤害性轻微的甩尾反应的抑制，在幼稚的小鼠和小鼠呈现耐受性和依赖于吗啡颗粒植入测量。然而，对吗啡的耐受性和依赖性的发展不受HC-3的影响。尽管无论HC-3是在吗啡依赖性形成之前还是之后给药，纳洛酮催促戒断跳跃均得到增强，但突然戒断期间的体重减轻不受HC-3的影响。这些结果表明，虽然吗啡的一些急性和戒断作用可能与乙酰胆碱直接或间接相关，但这些作用似乎不是引起耐受性和依赖性发展的主要过程。
Administration of HC-3 intracerebrally at a dose which reduced brain acetylcholine (ACh) without any change in choline (Ch) levels antagonized morphine antinociception slightly as measured by inhibition of the tail-flick response, in both naive mice and in mice rendered tolerant to and dependent on morphine by pellet implantation. However, the development of tolerance to morphine and of dependence on morphine were not affected by HC-3. Although naloxone precipitated withdrawal jumping was enhanced irrespective of whether the HC-3 was administered before or after the dependence on morphine had developed, body weight loss during abrupt withdrawal was unaffected by HC-3. The results indicate that although some of the acute and withdrawal effects of morphine may be associated either directly or indirectly with acetylcholine, these actions do not appear to be the primary process responsible for initiating the development of tolerance and dependence.