PET Imaging of αvβ3 Expression in Cancer Patients
PET Imaging of αvβ3 Expression in Cancer Patients
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DOI：
10.1007/978-1-60761-901-7_13
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发表时间：
2011-01-01
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影响因子：
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通讯作者：
Schwaiger, Markus
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文献类型：
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作者：
Beer, Ambros J.;Schwaiger, Markus
近年来，恶性疾病中α v β 3表达的影像学研究得到了广泛的研究，主要是因为整合素α v β 3表达水平可能是血管生成活性的替代参数。大多数研究都是使用临床前肿瘤模型进行的，但最近首次公布了患者中α v β 3表达的成像结果。使用的第一种方法是放射性示踪剂方法，其中示踪剂用于正电子发射断层扫描（PET），如[F-18]Galacto-RGD或示踪剂用于单光子发射计算机断层扫描（SPECT），如[Tc-99m]NC100692。在本文中，我们将重点讨论用示踪剂[F-18]Galacto-RGD对α v β 3表达进行PET成像的实验设计和方法。我们将讨论图像获取和解释中常见的困难和陷阱。最后，将PET的性能与其他成像α v β 3表达的方法进行比较，如磁共振成像、超声或光学成像。
Imaging of alpha v beta 3 expression in malignant diseases has been extensively studied in the last years, mainly because the level of integrin alpha v beta 3 expression might be a surrogate parameter of angiogenic activity. Most studies have been performed using preclinical tumor models but recently first results if imaging alpha v beta 3 expression in patients have been published. The first approach used was the radiotracer approach with tracers for positron emission tomography (PET) like [F-18]Galacto-RGD or tracers for single photon emission computed tomography (SPECT) like [Tc-99m]NC100692. In this article we will focus on the experimental design and methodology of PET imaging of alpha v beta 3 expression with the tracer [F-18]Galacto-RGD. Common difficulties and pitfalls in image acquisition and interpretation will be discussed. Finally, the performance of PET will be compared to other methods of imaging of alpha v beta 3 expression, like magnetic resonance imaging, ultrasound, or optical imaging.