Monitoring glaucomatous progression using a novel heidelberg retina tomograph event analysis
Monitoring glaucomatous progression using a novel heidelberg retina tomograph event analysis
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DOI：
10.1016/j.ophtha.2007.01.035
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发表时间：
2007-11-01
期刊：
影响因子：
13.7
通讯作者：
Garway-Heath, David F.
中科院分区：
文献类型：
--
作者：
Fayers, Tessa;Strouthidis, Nicholas G.;Garway-Heath, David F.
目的.描述事件分析（EA）用于监测海德堡视网膜断层扫描（HRT）进展，并通过应用纵向数据建立特异性、检出率和与视野进展的一致性。设计：回顾性分析随机对照试验的数据。参与者：198名高眼压患者和21名对照受试者。方法：变化标准来自不同水平的图像质量的边缘面积（RA）的重复性系数。将事件分析1（EA 1）至EA 4应用于从高眼压组和对照组获得的HRT图像的纵向系列：EA 1（在1个或多个扇区的3次连续测试中有2次确认变化），EA 2（在2个或多个扇区的3次测试中有2次确认变化），EA 3（在1个或多个扇区的3次测试中有3次确认变化），EA 4（在2个或多个扇区的3次测试中有3次确认变化）。通过进展对照和显著改善受试者的比例估计特异性（1减去假阳性结果）。进展率与晚期青光眼干预研究（AGIS）视野（VF）标准、HRT趋势分析和VF趋势分析进行比较，特异性匹配为95%。主要结果测量：估计特异性、进展率和进展技术之间的一致性。特异性估计值为76.2%-88.1%（EA 1）、94.1%-95.2%（EA 2）、92.2%-95.2%（EA 3）和99.1%-100%（EA 4）。在高眼压（OHT）受试者中，每种策略分别有45.4%、28.3%、26.3%和16.2%的受试者发生进展。特异性为95%，12.1%的OHT受试者根据EA 2和AGIS标准均发生进展，中位进展时间分别为3.2年和3.6年。仅根据EA 2，16.2%进展，仅根据AGIS标准，9.6%进展。RA趋势分析确定12%的OHT科目为progressing.Conclusions：HRT EA代表一种简单的技术，考虑到图像质量。在该队列中，其进展检出率（95%特异性）高于RA趋势分析和VF进展标准。
Purpose. To describe an event analysis (EA) for monitoring Heidelberg Retina Tomograph (HRT) progression and to establish specificity, detection rate, and agreement with visual field progression by application to longitudinal data.Design: Retrospective analysis of data from a randomized controlled trial.Participants: One hundred ninety-eight ocular hypertensive and 21 control subjects.Methods: Change criteria were derived from rim area (RA) repeatability coefficients for different levels of image quality. Event analysis 1 (EA1) through EA4 were applied to longitudinal series of HRT images acquired from the ocular hypertensive and the control cohorts: EA1 (change confirmed in 2 of 3 consecutive tests in 1 or more sector), EA2 (2 of 3 in 2 or more sectors), EA3 (3 of 3 in 1 or more sector), EA4 (3 of 3 in 2 or more sectors). Specificity (1 minus false positive results) was estimated by the proportions of progressing controls and significantly improving subjects. Progression rates were compared with Advanced Glaucoma Intervention Study (AGIS) visual field (VF) criteria, an HRT trend analysis, and a VF trend analysis, with specificity matched at 95%.Main Outcome Measures: Estimated specificity, progression rate, and agreement between progression techniques.Results: Specificity estimates were 76.2% to 88.1 % (EA1), 94.1 % to 95.2% (EA2), 92.2% to 95.2% (EA3), and 99.1 % to 100% (EA4). Of ocular hypertensive (OHT) subjects, 45.4%, 28.3%, 26.3%, and 16.2% were identified as progressing by each strategy, respectively. With specificity at 95%, 12.1% of OHT subjects progressed by both EA2 and AGIS criteria, with a median time to progression of 3.2 and 3.6 years, respectively. By EA2 alone, 16.2% progressed, and 9.6% progressed by AGIS criteria alone. The RA trend analysis identified 12% of OHT subjects as progressing.Conclusions: The HRT EA represents a simple technique, taking into account image quality. In this cohort, it had a higher detection rate of progression, at 95% specificity, than RA trend analysis and the VF progression criteria.