Distribution of beta-amyloid in the canine brain.
Distribution of beta-amyloid in the canine brain.
复制标题
β-淀粉样蛋白在犬脑中的分布。
DOI：
10.1097/00001756-199703030-00038
复制
发表时间：
1997
期刊：
影响因子：
1.7
通讯作者：
Russell,MJ
中科院分区：
文献类型：
--
作者：
Hou,Y;White,RG;Bobik,M;Marks,JS;Russell,MJ
THE distribution of amyloid-β-protein (Aβ) in the canine brain was demonstrated by immunochemistry on serially sectioned tissues from 10 aged mixed breed dogs. Summation of quantitative data and relegation to anatomical sites for the 10 dogs showed Aβ to be widely distributed in the cortex and hippocampus while completely absent in the brain stem and cerebellum. The highest density of Aβ was in the dentate gyrus of the hippocampus. Cortical areas exhibiting the greatest Aβ deposition were the posterior and medial suprasylvius gyrus and the proreus gyrus of the frontal lobe. Unlike humans the canine entorhinal cortex, amygdala, basal ganglia and olfactory bulbs were rarely affected. This suggested that the highly developed olfactory pathways of the canine are generally spared from Aβ deposition.
