Delayed regional metabolic actions of phencyclidine.
Delayed regional metabolic actions of phencyclidine.
复制标题
苯环己哌啶的局部代谢作用延迟。
DOI：
10.1016/0014-2999(93)90926-9
复制
发表时间：
1993
影响因子：
5
通讯作者：
Tamminga,CA
中科院分区：
文献类型：
--
作者：
Gao,XM;Shirakawa,O;Du,F;Tamminga,CA
苯环利定（PCP）是一种滥用的拟精神病药物，在人类中产生精神变化和表现，使人联想到精神分裂症，尽管这些作用的机制仍然未知。我们在这里报告了PCP对局部脑葡萄糖代谢作用的双相时间过程，持续时间超过48小时。单次给予PCP（8.6 mg/kg）后，葡萄糖代谢最初增加（3 h），随后降低（24 h），直至48 h才恢复至基线水平。单次较低剂量的五氯苯酚（0.86毫克/千克），被认为是对NMDA-PCP受体具有选择性作用的剂量，不会产生早期代谢变化（3小时），但复制了局部代谢减退，尽管在24小时时强度较低。延迟性脑代谢减退似乎与PCP诱导的压后皮质细胞内空泡化无关。这些代谢变化可能与PCP的拟精神病效应有关，因此可能与人类精神病有关。
Phencyclidine (PCP), a psychotomimetic drug of abuse, produces mental changes and manifestations in humans which are reminiscent of schizophrenia, though the mechanism of these actions remains unknown. We report here a biphasic time course of PCP action on regional cerebral glucose metabolism extending over 48 h. A single dose of PCP (8.6 mg/kg) produces an initial increase in glucose metabolism (at 3 h) and a later decrease in glucose metabolism (at 24 h) without a return to baseline until 48 h. A single lower dose of PCP (0.86 mg/kg), a dose which is considered selective for action at the NMDA-PCP receptor, produces no early metabolic change (at 3 h), but replicates the regional hypometabolism albeit less intense at 24 h. The delayed cerebral hypometabolism does not appear to be related to PCP-induced intracellular vacuolization, seen in the retrosplenial cortex. These metabolic changes may be associated with the psychotomimetic effects of PCP and thus may be relevant to psychosis in humans.