Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages
Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages
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DOI：
10.1016/s0960-894x(99)00623-x
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发表时间：
1999-12-20
影响因子：
2.7
通讯作者：
Sporn, MB
中科院分区：
文献类型：
--
作者：
Honda, T;Rounds, BV;Sporn, MB
设计并合成了具有A和C环修饰的新型齐墩烷三萜。其中，甲基2-羧基-3,12-二氧齐烷-1,9-二烯-28-oic酸与我们之前合成的2-氰基-3,12-二氧齐烷-1,9-二烯-28-oic酸（CDDO）对干扰素γ诱导的小鼠巨噬细胞产生一氧化氮具有相似的高抑制活性（IC50 = 0.8 nM）。1999爱思唯尔科学有限公司版权所有。
Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-gamma in mouse macrophages. (C) 1999 Elsevier Science Ltd. All rights reserved.