Fission-neutron-induced expression of a tumour-associated antigen in human cell hybrids (HeLa x skin fibroblasts): evidence for increased expression at low dose rate.
Fission-neutron-induced expression of a tumour-associated antigen in human cell hybrids (HeLa x skin fibroblasts): evidence for increased expression at low dose rate.
复制标题
裂变中子诱导的人类细胞杂交体（HeLa x 皮肤成纤维细胞）中肿瘤相关抗原的表达：低剂量率下表达增加的证据。
DOI：
10.1080/09553009014552021
复制
发表时间：
1990
影响因子：
2.6
通讯作者：
Sun,C
中科院分区：
文献类型：
--
作者：
Redpath,JL;Hill,CK;Jones,CA;Sun,C
研究了在平均能量为0.85 MeV的裂变中子（Janus反应堆，Argonne国家实验室）以0.086 cGy/min和10.3 cGy/min两种剂量率照射后，人细胞杂交系（HeLa ×皮肤成纤维细胞）中肿瘤相关抗原的诱导。获得的剂量-反应数据表明，低剂量率诱导肿瘤相关抗原表达的效果是高剂量率的2.9倍，而在细胞杀伤方面没有显著的剂量-率效应。这些结果与先前使用Janus反应堆的中子对C3H10T½细胞和叙利亚仓鼠胚胎细胞进行肿瘤转化的观察结果在质量上是一致的。
The induction of a tumour-associated antigen in a human cell hybrid line (HeLa × skin fibroblast) following exposure to fission neutrons of average energy 0·85 MeV (Janus reactor, Argonne National Laboratory) at two dose rates, 0·086 and 10·3 cGy/min, has been examined. The dose-response data obtained indicate the lower dose rate to be 2·9-fold more effective than the higher in inducing expression of the tumour-associated antigen, while there was no significant dose-rate effect in terms of cell killing. These results are qualitatively in agreement with previous observations using neutrons from the Janus reactor for the neoplastic transformation of C3H10T½ cells and Syrian hamster embryo cells.