Spatially and temporally restricted expression of Pax2 during murine neurogenesis.
Spatially and temporally restricted expression of Pax2 during murine neurogenesis.
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发表时间：
1990-08
期刊：
影响因子：
4.6
通讯作者：
H. Nornes;G. Dressler;E. Knapik;U. Deutsch;Peter Gruss
中科院分区：
文献类型：
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作者：
H. Nornes;G. Dressler;E. Knapik;U. Deutsch;Peter Gruss
通过原位杂交在发育中的中枢神经系统中检查鼠含配对盒基因Pax2的表达。Pax2表达沿神经管的初级分裂的边界被检测到沿着。最初，Pax2表达于脑室区，位于界沟两侧的两个细胞室中，并沿着整个菱脑和脊髓。在以后的时间，Pax2仅限于已经迁移到中间区的特定区域的后代细胞。在眼睛中，Pax2的表达仅限于视杯和视柄的腹侧半部分，然后是视盘和神经。在耳中，表达仅限于形成神经元成分的耳泡区域。Pax2表达的短暂性和受限制的性质表明，这种小鼠分割基因同源物也可能建立房室边界，并有助于神经元身份的规范，某些果蝇分割基因。
The expression of the murine paired-box-containing gene, Pax2, is examined in the developing central nervous system by in situ hybridization. Pax2 expression is detected along the boundaries of primary divisions of the neural tube. Initially, Pax2 is expressed in the ventricular zone in two compartments of cells on either side of the sulcus limitans and along the entire rhombencephalon and spinal cord. At later times, Pax2 is restricted to progeny cells that have migrated to specific regions of the intermediate zone. In the eye, Pax2 expression is restricted to the ventral half of the optic cup and stalk and later to the optic disc and nerve. In the ear, expression is restricted to regions of the otic vesicle that form neuronal components. The transient and restricted nature of Pax2 expression suggests that this murine segmentation gene homologue may also establish compartmental boundaries and contribute to the specification of neuronal identity, as do certain Drosophila segmentation genes.