ANTIGENICITY OF MURINE SKIN TUMORS INDUCED BY ULTRAVIOLET-LIGHT
ANTIGENICITY OF MURINE SKIN TUMORS INDUCED BY ULTRAVIOLET-LIGHT
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DOI：
10.1093/jnci/53.5.1333
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发表时间：
1974-01-01
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影响因子：
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通讯作者：
KRIPKE, ML
中科院分区：
文献类型：
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作者：
KRIPKE, ML
与化学致癌物诱导的肿瘤相比，紫外线（UV）光慢性治疗诱导的小鼠皮肤肿瘤表现出出乎意料的高抗原性。紫外线诱导的梭形细胞肿瘤完全消退时，转移到正常的同基因受体，并逐步增长，只有在免疫抑制的主机。由紫外线产生的鳞状细胞癌也表现出这种不寻常的行为，但程度较轻。通过体内交叉保护试验，在这些肿瘤中未检测到交叉反应性。
Murine skin tumors induced by chronic treatment with ultraviolet (UV) light exhibited an unexpectedly high degree of antigenicity compared with tumors induced by chemical carcinogens. UV-induced spindle cell tumors completely regressed when transferred to normal syngeneic recipients and grew progressively only in immunosuppressed hosts. Squamous cell carcinomas produced by UV light also showed this unusual behavior, but to a lesser extent. No cross-reactivity was detected among these tumors by in vivo cross-protection tests.