BIPHASIC EFFECTS OF INTRA-ACCUMBENS HISTAMINE ADMINISTRATION ON SPONTANEOUS MOTOR-ACTIVITY IN THE RAT - A ROLE FOR CENTRAL HISTAMINE-RECEPTORS
BIPHASIC EFFECTS OF INTRA-ACCUMBENS HISTAMINE ADMINISTRATION ON SPONTANEOUS MOTOR-ACTIVITY IN THE RAT - A ROLE FOR CENTRAL HISTAMINE-RECEPTORS
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DOI：
10.1111/j.1476-5381.1988.tb11767.x
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发表时间：
1988-12-01
影响因子：
7.3
通讯作者：
BENNETT, GW
中科院分区：
文献类型：
--
作者：
BRISTOW, LJ;BENNETT, GW
本文研究了大鼠腹腔注射组胺及其有关化合物对自发活动的影响。组胺（1-200 μ g）的微量注射诱导大鼠活动的剂量依赖性双相变化，其由最初的短暂活动减退反应和随后的显著活动过度阶段组成。组胺代谢产物n-远甲基组胺无作用。用H1受体拮抗剂美托咪胺（10 μ g）预处理阻断了活动减退反应并显著减弱了组胺诱导的活动过度。相反，用H2受体拮抗剂SKF 93479预处理对组胺诱导的行为没有影响。微量注射H1受体激动剂2-thiazolylethylamine诱导显着的多动症反应，但不像组胺的反应，有没有最初的活动减退。H2受体激动剂二甲双胍对大鼠行为无明显影响。非选择性组胺激动剂N α-受体激动剂的内注射甲基组胺或N α，n. α-二甲基组胺诱导明显的活动减退和活动过度反应，这与组胺的作用相当。目前的结果表明，组胺，H2受体介导的觉醒在脑桥核以下短暂的活动减退，可能是由于突触前H3受体的激活。
The effect of intra-accumbens injection of histamine and related compounds on the spontaneous motor activity of the rat has been investigated. Microinjections of histamine (1-200 .mu.g) induced dose-dependent, biphasic changes in rat activity consisting of an initial brief hypoactivity response followed by a marked hyperactivity phase. The histamine metabolite, n-tele-methylhistamine was without effect. Pretreatment with the H1-receptor antagonist mepyramine (10 .mu.g) blocked the hypoactivity response and markedly attentuated histamine-induced hyperactivity. In contrast, pretreatment with the H2-receptor antagonist SKF93479 had no effect on histamine-induced behavior. Microinjection of the H1-receptor agonist 2-thiazolylethylamine induced a marked hyperactivity response, but unlike the response to histamine, there was no initial hypoactivity. The H2-receptor agonist dimaprit had no apparent behavioral effects following intra-accumbens injection. Intra-accumbens injection of the non-selective histamine agonists n.alpha.-methylhistamine or n.alpha., n.alpha.-dimethylhistamine induced both marked hypoactivity and hyperactivity responses which were comparable with the effects of histamine. The present results demonstrate a histamine, H2-receptor-mediated arousal in the nucleus accumbens which follows transitory hypoactivity, possibly due to activation of presynaptic H3-receptors.