Determination of individual stimulus-response curves in the visual cortex
Determination of individual stimulus-response curves in the visual cortex
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DOI：
10.1002/hbm.10067
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发表时间：
2002-12-01
影响因子：
4.8
通讯作者：
Barkhof, F
中科院分区：
文献类型：
--
作者：
Hagenbeek, RE;Rombouts, SARB;Barkhof, F
视觉皮层中的激活通常使用针对单个闪烁频率的开-关范例中的组平均变化来研究。我们使用功能性磁共振成像（fMRI）来表征视觉皮层中的刺激-反应曲线作为个体受试者闪烁频率的函数，使用0至30 Hz之间具有17个频率步长的LED护目镜。10个健康的年轻人进行了研究，在两个不同的场合（平均间隔; 22天）。除了一个受试者外，所有受试者的数据都可以拟合出三阶多项式曲线。根据响应曲线，我们计算了峰值响应（响应幅度最大的频率）、8 Hz和峰值频率之间响应幅度的百分比变化（相对差）以及响应的平均斜率（朝向峰值）。在这两种情况下，我们可以确定每例受试者的峰值响应，受试者内变异性较小。两个疗程之间的峰值响应的平均绝对差为1.37 Hz（范围，0.2-4.3 Hz），表明峰值频率对于给定个体而言相当稳定。总之，我们的研究说明了功能磁共振成像的能力，检查在视觉皮层的刺激反应曲线在个别科目。根据我们的研究结果，峰值响应和响应斜率在受试者中似乎具有高度可重复性。对刺激-反应曲线的类似分析可以适用于其他类型的刺激。(C)2002 Wiley-Liss，Inc.
Activation in the visual cortex is typically studied using group average changes in an on-off paradigm for a single flicker frequency. We used functional magnetic resonance imaging (fMRI) to characterize the stimulus-response curve in the visual cortex as a function of flicker frequency in individual subjects, using LED goggles with 17 frequency steps between 0 and 30 Hz. Ten healthy young individuals were studied on two different occasions (mean interval; 22 days). In all but one subject, a third-order polynomial curve could be fitted to the data. From the response curve we calculated the peak response (the frequency where the response amplitude was maximal), the percentage change (relative difference) of the response amplitudes between 8 Hz and the peak frequency, and the average slope of response (towards the peak). On both occasions we could determine a peak response for each subject with small within-subject variability. The average absolute difference in peak response between both sessions was 1.37 Hz (range, 0.2-4.3 Hz), indicating that the peak frequency is rather stable for a given individual. In conclusion, our study illustrates the ability of fMRI to examine the stimulus-response curve in individual subjects in the visual cortex. Based on our findings, the peak response and the slope of response seem highly reproducible within subjects. A similar analysis of the stimulus-response curve may be applicable to other types of stimuli. (C) 2002 Wiley-Liss, Inc.