Reduced Palatability in Lithium- and Activity-Based, but Not in Amphetamine-Based, Taste Aversion Learning
Reduced Palatability in Lithium- and Activity-Based, but Not in Amphetamine-Based, Taste Aversion Learning
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DOI：
10.1037/a0012703
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发表时间：
2008-10-01
影响因子：
1.9
通讯作者：
Hayward, Andrew J.
中科院分区：
文献类型：
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作者：
Dwyer, Dominic M.;Boakes, Robert A.;Hayward, Andrew J.
基于氯化锂（实验1）、安非他明（实验2）的条件性味觉厌恶（CTA）。和车轮运行（实验3）进行了检查，使用舔的微观结构的分析，以测量作为条件刺激（CS）的味道的适口性。配对糖精与安非他明减少糖精的摄入量，而不减少舔集群的大小，初始舔率，或一个集群内的舔间隔（ILI）的分布。相比之下，糖精与锂或轮运行配对减少糖精摄入量以及舔簇大小，初始舔率和ILI在簇内的分布。由于舔簇的大小，初始舔率，和ILI分布可以用作指标的刺激适口性，目前的结果表明，味觉厌恶的基础上，无论是锂或活动降低了CS的适口性。这表明，基于锂和车轮运行的厌恶涉及对CS味道的条件性恶心。安非他明类CTA的舔体微观结构没有类似的变化，这与其他证据一致，表明这不涉及恶心。
Conditioned taste aversions (CTA) based on lithium chloride (Experiment 1), amphetamine (Experiment 2). and wheel running (Experiment 3) were examined using the analysis of the microstructure of licking to measure the palatability of the taste serving as the conditioned stimulus (CS). Pairing saccharin with amphetamine reduced saccharin intake without reducing the size of licking clusters, initial lick rate, or the distribution of inter-lick intervals (ILIs) within a cluster. By contrast, pairing saccharin with lithium or wheel-running reduced saccharin intake as well as lick cluster size, initial lick rate, and the distribution of ILIs within a cluster. As lick cluster size, initial lick rate, and ILI distribution can be used as indices of stimulus palatability, the current results indicate that taste aversions based on either lithium or activity reduced the palatability of the CS. This suggests that aversions based on both lithium and wheel running involve conditioned nausea to the CS taste. The absence of similar changes in licking microstructure with amphetamine-based CTA is consistent with other evidence indicating this does not involve nausea.