Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians.
Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians.
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DOI：
10.1093/molbev/msab053
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发表时间：
2021-05-19
影响因子：
10.7
通讯作者：
Norman PJ
中科院分区：
文献类型：
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作者：
Deng Z;Zhen J;Harrison GF;Zhang G;Chen R;Sun G;Yu Q;Nemat-Gorgani N;Guethlein LA;He L;Tang M;Gao X;Cai S;Palmer WH;Shortt JA;Gignoux CR;Carrington M;Zou H;Parham P;Hong W;Norman PJ
人类自然杀伤(NK)细胞对控制感染、癌症和胎儿发育至关重要。NK细胞的功能受多态抑制性杀伤细胞免疫球蛋白样受体(KIR)和组织细胞上表达的多态HLA-A、-B和-C配体相互作用的调节。所有的人类白细胞抗原-C等位基因都编码一个KIR配体，并有助于生殖和免疫。相比之下，只有一些HLA-A和-B等位基因编码KIR配体，它们侧重于免疫。通过对KIR和HLA-A、-B和-C基因的高分辨率分析，我们发现中国南方汉族人群中抑制性KIR与HLA-A和-B之间的相互作用显著丰富。这种浓缩通过与邻近群体的群体混合产生了大量的输入，这些群体贡献了表达KIR配体B*46：01和B*58：01的人类白细胞抗原I类单倍型，这些单倍型随后通过自然选择上升到高频。因此，80%以上的南方汉族人类白细胞抗原单倍型编码一个以上的KIR配体。作为对大量KIR配体的补充，CHS KIR基因座结合了高频率表达有效抑制性KIR的基因和低频率表达激活KIR的基因。南方汉族着丝粒KIR区编码强大的、保守的、抑制性的HLA-C特异性受体，端粒区提供大量和多样性的抑制性的HLA-A和B特异性受体。在所有这些特征中，CHS代表了其他东亚人，他们的NK细胞谱系因此在数量、多样性和效应器强度方面都得到了增强，可能增强了对地方性病毒感染的抵抗力。
Human natural killer (NK) cells are essential for controlling infection, cancer, and fetal development. NK cell functions are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA-A, -B, and -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand and contribute to reproduction and immunity. In contrast, only some HLA-A and -B alleles encode KIR ligands and they focus on immunity. By high-resolution analysis of KIR and HLA-A, -B, and -C genes, we show that the Chinese Southern Han (CHS) are significantly enriched for interactions between inhibitory KIR and HLA-A and -B. This enrichment has had substantial input through population admixture with neighboring populations, who contributed HLA class I haplotypes expressing the KIR ligands B*46:01 and B*58:01, which subsequently rose to high frequency by natural selection. Consequently, over 80% of Southern Han HLA haplotypes encode more than one KIR ligand. Complementing the high number of KIR ligands, the CHS KIR locus combines a high frequency of genes expressing potent inhibitory KIR, with a low frequency of those expressing activating KIR. The Southern Han centromeric KIR region encodes strong, conserved, inhibitory HLA-C-specific receptors, and the telomeric region provides a high number and diversity of inhibitory HLA-A and -B-specific receptors. In all these characteristics, the CHS represent other East Asians, whose NK cell repertoires are thus enhanced in quantity, diversity, and effector strength, likely augmenting resistance to endemic viral infections.
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影响因子：
3.7
作者：
Abi-Rached L;Gouret P;Yeh JH;Di Cristofaro J;Pontarotti P;Picard C;Paganini J
通讯作者：
Paganini J
影响因子：
24.8
作者：
Boelen L;Debebe B;Silveira M;Salam A;Makinde J;Roberts CH;Wang ECY;Frater J;Gilmour J;Twigger K;Ladell K;Miners KL;Jayaraman J;Traherne JA;Price DA;Qi Y;Martin MP;Macallan DC;Thio CL;Astemborski J;Kirk G;Donfield SM;Buchbinder S;Khakoo SI;Goedert JJ;Trowsdale J;Carrington M;Kollnberger S;Asquith B
通讯作者：
Asquith B
影响因子：
7.3
作者：
Deng, Zhihui;Zhao, Jun;Norman, Paul J.
通讯作者：
Norman, Paul J.
影响因子：
20.3
作者：
Andersson, Sandra;Fauriat, Cyril;Malmberg, Karl-Johan
通讯作者：
Malmberg, Karl-Johan
中国汉族人群杀伤细胞免疫球蛋白样受体（KIR）基因型和单倍型的特征
影响因子：
--
作者：
Bao, X.;Wang, M.;He, J.
通讯作者：
He, J.