ASSOCIATION BETWEEN SALIVARY FLOW-RATE AND THE USE OF SYSTEMIC MEDICATION AMONG 76-YEAR-OLD, 81-YEAR-OLD, AND 86-YEAR-OLD INHABITANTS IN HELSINKI, FINLAND
ASSOCIATION BETWEEN SALIVARY FLOW-RATE AND THE USE OF SYSTEMIC MEDICATION AMONG 76-YEAR-OLD, 81-YEAR-OLD, AND 86-YEAR-OLD INHABITANTS IN HELSINKI, FINLAND
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DOI：
10.1177/00220345920710120401
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发表时间：
1992-12-01
影响因子：
7.6
通讯作者：
MAKILA, E
中科院分区：
文献类型：
--
作者：
NARHI, TO;MEURMAN, JH;MAKILA, E
这项研究的目的是在76岁、81岁和86岁的有代表性的受试者中检查唾液流率及其与药物使用的关系，总计368人。在这项研究中，23%(n=80)的受试者没有服用药物。每日服用1~3种药物者占47%(n=168)，使用4种以上药物者占30%(n=104)。最常用的药物是硝酸盐、洋地黄或抗心律失常药(47.7%)、镇痛剂和解热药(32.6%)和利尿剂(29.5%)。86岁年龄组的平均每日使用量显著高于两个年轻年龄组(p<；0.01)。在未服用药物的受试者中，76岁的受试者的刺激性唾液流率显著高于81岁的受试者(p<；0.05)。未服用药物的女性的非刺激性唾液流率和刺激性唾液流率显著低于男性(P<；0.01)和刺激性唾液流率(P<；0.05)。76岁的服药者的刺激性唾液流率也显著高于86岁的服药者(p<；0.05)。非刺激性唾液流率在三个年龄组之间无统计学差异。服用药物的女性表现出明显低于男性的非刺激性唾液流率(p<；0.001)，尽管刺激唾液流率的差异并不显著。未服药的人和每天服用四到六种或七种以上处方药的人之间的唾液流率在统计上有显著差异。
The aim of this study was to examine salivary flow rate and its association with the use of medication in a representative sample of 76-, 81-, and 86-year-old subjects, totaling 368.In this study, 23% (n = 80) of the subjects were unmedicated. From one to three daily medications were used by 47% (n = 168) and more than four medications by 30% (n = 104). The most commonly used medications were nitrates, digitalis or anti-arrhythmic drugs (47.7%), analgesics and antipyretics (32.6%), and diuretics (29.5%). The mean number used daily was significantly higher in 86-year-olds than in the two younger age groups (p < 0.01). No significant differences in this respect were found between genders.Among the unmedicated subjects, 76-year-olds had significantly higher stimulated salivary flow rates than did the 81-year-olds (p < 0.05). Unmedicated women showed significantly lower unstimulated (p < 0.01) and stimulated flow rates than did men (p < 0.05).Stimulated salivary flow rate was also significantly higher in the 76-year-old medicated subjects than in the medicated 86-year-old subjects (p < 0.05). No statistically significant differences were found in unstimulated salivary flow rates among the three age groups. Medicated women showed significantly lower unstimulated salivary flow rates than men (p < 0.001), although the difference in stimulated saliva flow was not significant. A statistically significant difference in unstimulated and stimulated salivary flow rates was found between unmedicated persons and those who took from four to six, or more than seven, prescribed medications daily.