Plasmodium falciparum susceptibility to antimalarial drugs: global data issued from the Pasteur Institutes international network
Plasmodium falciparum susceptibility to antimalarial drugs: global data issued from the Pasteur Institutes international network
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DOI：
10.1051/medsci/2013296020
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发表时间：
2013-06-01
影响因子：
0.7
通讯作者：
Mercereau-Puijalon，Odile
中科院分区：
文献类型：
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作者：
Menard，Didier;Ariey，Frederic;Mercereau-Puijalon，Odile
位于非洲、东南亚和南美洲的巴斯德研究所国际网络内的疟疾研究单位与国家疟疾控制方案密切合作多年。依靠拥有设备齐全的实验室和科学专业知识的技术平台，他们共同努力培训年轻科学家，并开发类似的方案，以便进行全面比较，从而走在抗疟疾耐药性研究的前沿。包括基础和业务研究，他们开展区域和国际项目，目的是(1)检测抗疟疾药物耐药寄生虫的出现并评估其时空分布，(2)开发体外和分子工具，(3)确定与抗疟疾药物耐药寄生虫的出现和传播有关的流行病学因素，以及(4)了解与耐药寄生虫有关的分子和细胞机制。在这次审查中，将介绍自2000年以来获得的方法方法和数据。
Malaria research units within the Institut Pasteur international network (RIIP-Palu) located in Africa, in South-East Asia and in South America, work for many years in close collaboration with the National malaria control programmes. Relying on technical platforms with well-equipped laboratories and scientific expertise, they are at the forefront of research on the antimalarial drug resistance by working together for training young scientists and developping similar protocols allowing comprehensive comparisons. Including fundamental and operational researches, they conduct regional and international projects which aim (1) to detect the emergence of antimalarial drugs resistant parasites and to evaluate their spatio-temporal distribution,(2) to develop in vitro and molecular tools,(3) to identify epidemiological factors involved in the emergence and the spread of antimalarial drugs resistant parasites and (4) to understand the molecular and cellular mechanisms implicated in resistance. In this review, will be presented methodological approaches and data obtained since 2000.